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Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets

Dietary supplementations with n-3 polyunsaturated fatty acid (PUFA) have been explored in autism spectrum disorder (ASD) but their efficiency and potential in ameliorating cardinal symptoms of the disease remain elusive. Here, we compared a n-3 long-chain (LC) PUFA dietary supplementation (n-3 supp)...

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Autores principales: Turpin, Valentine, Schaffhauser, Maud, Thabault, Mathieu, Aubert, Agnès, Joffre, Corinne, Balado, Eric, Longueville, Jean-Emmanuel, Francheteau, Maureen, Burucoa, Christophe, Pichon, Maxime, Layé, Sophie, Jaber, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336048/
https://www.ncbi.nlm.nih.gov/pubmed/37433863
http://dx.doi.org/10.1038/s41598-023-38423-z
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author Turpin, Valentine
Schaffhauser, Maud
Thabault, Mathieu
Aubert, Agnès
Joffre, Corinne
Balado, Eric
Longueville, Jean-Emmanuel
Francheteau, Maureen
Burucoa, Christophe
Pichon, Maxime
Layé, Sophie
Jaber, Mohamed
author_facet Turpin, Valentine
Schaffhauser, Maud
Thabault, Mathieu
Aubert, Agnès
Joffre, Corinne
Balado, Eric
Longueville, Jean-Emmanuel
Francheteau, Maureen
Burucoa, Christophe
Pichon, Maxime
Layé, Sophie
Jaber, Mohamed
author_sort Turpin, Valentine
collection PubMed
description Dietary supplementations with n-3 polyunsaturated fatty acid (PUFA) have been explored in autism spectrum disorder (ASD) but their efficiency and potential in ameliorating cardinal symptoms of the disease remain elusive. Here, we compared a n-3 long-chain (LC) PUFA dietary supplementation (n-3 supp) obtained from fatty fish with a n-3 PUFA precursor diet (n-3 bal) obtained from plant oils in the valproic acid (VPA, 450 mg/kg at E12.5) ASD mouse model starting from embryonic life, throughout lactation and until adulthood. Maternal and offspring behaviors were investigated as well as several VPA-induced ASD biological features: cerebellar Purkinje cell (PC) number, inflammatory markers, gut microbiota, and peripheral and brain PUFA composition. Developmental milestones were delayed in the n-3 supp group compared to the n-3 bal group in both sexes. Whatever the diet, VPA-exposed offspring did not show ASD characteristic alterations in social behavior, stereotypies, PC number, or gut microbiota dysbiosis while global activity, gait, peripheral and brain PUFA levels as well as cerebellar TNF-alpha levels were differentially altered by diet and treatment according to sex. The current study provides evidence of beneficial effects of n-3 PUFA based diets, including one without LCPUFAs, on preventing several behavioral and cellular symptoms related to ASD.
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spelling pubmed-103360482023-07-13 Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets Turpin, Valentine Schaffhauser, Maud Thabault, Mathieu Aubert, Agnès Joffre, Corinne Balado, Eric Longueville, Jean-Emmanuel Francheteau, Maureen Burucoa, Christophe Pichon, Maxime Layé, Sophie Jaber, Mohamed Sci Rep Article Dietary supplementations with n-3 polyunsaturated fatty acid (PUFA) have been explored in autism spectrum disorder (ASD) but their efficiency and potential in ameliorating cardinal symptoms of the disease remain elusive. Here, we compared a n-3 long-chain (LC) PUFA dietary supplementation (n-3 supp) obtained from fatty fish with a n-3 PUFA precursor diet (n-3 bal) obtained from plant oils in the valproic acid (VPA, 450 mg/kg at E12.5) ASD mouse model starting from embryonic life, throughout lactation and until adulthood. Maternal and offspring behaviors were investigated as well as several VPA-induced ASD biological features: cerebellar Purkinje cell (PC) number, inflammatory markers, gut microbiota, and peripheral and brain PUFA composition. Developmental milestones were delayed in the n-3 supp group compared to the n-3 bal group in both sexes. Whatever the diet, VPA-exposed offspring did not show ASD characteristic alterations in social behavior, stereotypies, PC number, or gut microbiota dysbiosis while global activity, gait, peripheral and brain PUFA levels as well as cerebellar TNF-alpha levels were differentially altered by diet and treatment according to sex. The current study provides evidence of beneficial effects of n-3 PUFA based diets, including one without LCPUFAs, on preventing several behavioral and cellular symptoms related to ASD. Nature Publishing Group UK 2023-07-11 /pmc/articles/PMC10336048/ /pubmed/37433863 http://dx.doi.org/10.1038/s41598-023-38423-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Turpin, Valentine
Schaffhauser, Maud
Thabault, Mathieu
Aubert, Agnès
Joffre, Corinne
Balado, Eric
Longueville, Jean-Emmanuel
Francheteau, Maureen
Burucoa, Christophe
Pichon, Maxime
Layé, Sophie
Jaber, Mohamed
Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets
title Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets
title_full Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets
title_fullStr Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets
title_full_unstemmed Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets
title_short Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets
title_sort mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336048/
https://www.ncbi.nlm.nih.gov/pubmed/37433863
http://dx.doi.org/10.1038/s41598-023-38423-z
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