IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype

ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP synthase. The expression of IF1 in differentiated human and mouse cells is highly variable. In intestinal cells, the overexpression of IF1 protects against colon inflammation. Herein, we have developed a conditional IF1-kno...

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Detalles Bibliográficos
Autores principales: Domínguez-Zorita, Sonia, Romero-Carramiñana, Inés, Santacatterina, Fulvio, Esparza-Moltó, Pau B., Simó, Carolina, del-Arco, Araceli, Núñez de Arenas, Cristina, Saiz, Jorge, Barbas, Coral, Cuezva, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336053/
https://www.ncbi.nlm.nih.gov/pubmed/37433784
http://dx.doi.org/10.1038/s41419-023-05957-z

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