High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors

Single-cell nanopore sequencing of full-length mRNAs transforms single-cell multi-omics studies. However, challenges include high sequencing errors and dependence on short-reads and/or barcode whitelists. To address these, we develop scNanoGPS to calculate same-cell genotypes (mutations) and phenoty...

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Detalles Bibliográficos
Autores principales: Shiau, Cheng-Kai, Lu, Lina, Kieser, Rachel, Fukumura, Kazutaka, Pan, Timothy, Lin, Hsiao-Yun, Yang, Jie, Tong, Eric L., Lee, GaHyun, Yan, Yuanqing, Huse, Jason T., Gao, Ruli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336110/
https://www.ncbi.nlm.nih.gov/pubmed/37433798
http://dx.doi.org/10.1038/s41467-023-39813-7

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