Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal

The synergistic effect of alcohol and HCV mediated through TLR4 signaling transactivates NANOG, a pluripotency transcription factor important for the stemness of tumor-initiating stem-like cells (TICs). NANOG together with the PRC2 complex suppresses expression of oxidative phosphorylation (OXPHOS)...

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Detalles Bibliográficos
Autores principales: Yeh, Da-Wei, Liu, Cheng, Hernandez, Juan Carlos, Tahara, Stanley M., Tsukamoto, Hidekazu, Machida, Keigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336160/
https://www.ncbi.nlm.nih.gov/pubmed/37448562
http://dx.doi.org/10.1016/j.isci.2023.107035

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