Itaconate attenuates autoimmune hepatitis via PI3K/AKT/mTOR pathway-mediated inhibition of dendritic cell maturation and autophagy

Autoimmune hepatitis (AIH) results from an autoimmune-mediated chronic inflammatory response against liver cells. Defective self-tolerance and dysfunctional dendritic cells (DCs) play a regulatory role in AIH. Itaconate has recently attracted attention in the field of immunometabolism because of its...

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Detalles Bibliográficos
Autores principales: Zhang, Qiyu, Luo, Yang, Zheng, Qiuxia, Zhao, Haixia, Wei, Xiaofeng, Li, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336503/
https://www.ncbi.nlm.nih.gov/pubmed/37449121
http://dx.doi.org/10.1016/j.heliyon.2023.e17551

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