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Dual identity of tumor-associated macrophage in regulated cell death and oncotherapy

Tumor-associated macrophage (TAM) affects the intrinsic properties of tumor cells and the tumor microenvironment (TME), which can stimulate tumor cell proliferation, migration, and genetic instability, and macrophage diversity includes the diversity of tumors with different functional characteristic...

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Detalles Bibliográficos
Autores principales: Shao, Yingying, Wang, Yu, Su, Ranran, Pu, Weiling, Chen, Sibao, Fu, Leilei, Yu, Haiyang, Qiu, Yuling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336529/
https://www.ncbi.nlm.nih.gov/pubmed/37449180
http://dx.doi.org/10.1016/j.heliyon.2023.e17582
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author Shao, Yingying
Wang, Yu
Su, Ranran
Pu, Weiling
Chen, Sibao
Fu, Leilei
Yu, Haiyang
Qiu, Yuling
author_facet Shao, Yingying
Wang, Yu
Su, Ranran
Pu, Weiling
Chen, Sibao
Fu, Leilei
Yu, Haiyang
Qiu, Yuling
author_sort Shao, Yingying
collection PubMed
description Tumor-associated macrophage (TAM) affects the intrinsic properties of tumor cells and the tumor microenvironment (TME), which can stimulate tumor cell proliferation, migration, and genetic instability, and macrophage diversity includes the diversity of tumors with different functional characteristics. Macrophages are now a central drug target in various diseases, especially in the TME, which, as “tumor promoters” and “immunosuppressors”, have different responsibilities during tumor development and accompany by significant dynamic alterations in various subpopulations. Remodelling immunosuppression of TME and promotion of pre-existing antitumor immune responses is critical by altering TAM polarization, which is relevant to the efficacy of immunotherapy, and uncovering the exact mechanism of action of TAMs and identifying their specific targets is vital to optimizing current immunotherapies. Hence, this review aims to reveal the triadic interactions of macrophages with programmed death and oncotherapy, and to integrate certain relationships in cancer treatment.
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spelling pubmed-103365292023-07-13 Dual identity of tumor-associated macrophage in regulated cell death and oncotherapy Shao, Yingying Wang, Yu Su, Ranran Pu, Weiling Chen, Sibao Fu, Leilei Yu, Haiyang Qiu, Yuling Heliyon Review Article Tumor-associated macrophage (TAM) affects the intrinsic properties of tumor cells and the tumor microenvironment (TME), which can stimulate tumor cell proliferation, migration, and genetic instability, and macrophage diversity includes the diversity of tumors with different functional characteristics. Macrophages are now a central drug target in various diseases, especially in the TME, which, as “tumor promoters” and “immunosuppressors”, have different responsibilities during tumor development and accompany by significant dynamic alterations in various subpopulations. Remodelling immunosuppression of TME and promotion of pre-existing antitumor immune responses is critical by altering TAM polarization, which is relevant to the efficacy of immunotherapy, and uncovering the exact mechanism of action of TAMs and identifying their specific targets is vital to optimizing current immunotherapies. Hence, this review aims to reveal the triadic interactions of macrophages with programmed death and oncotherapy, and to integrate certain relationships in cancer treatment. Elsevier 2023-06-26 /pmc/articles/PMC10336529/ /pubmed/37449180 http://dx.doi.org/10.1016/j.heliyon.2023.e17582 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Shao, Yingying
Wang, Yu
Su, Ranran
Pu, Weiling
Chen, Sibao
Fu, Leilei
Yu, Haiyang
Qiu, Yuling
Dual identity of tumor-associated macrophage in regulated cell death and oncotherapy
title Dual identity of tumor-associated macrophage in regulated cell death and oncotherapy
title_full Dual identity of tumor-associated macrophage in regulated cell death and oncotherapy
title_fullStr Dual identity of tumor-associated macrophage in regulated cell death and oncotherapy
title_full_unstemmed Dual identity of tumor-associated macrophage in regulated cell death and oncotherapy
title_short Dual identity of tumor-associated macrophage in regulated cell death and oncotherapy
title_sort dual identity of tumor-associated macrophage in regulated cell death and oncotherapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336529/
https://www.ncbi.nlm.nih.gov/pubmed/37449180
http://dx.doi.org/10.1016/j.heliyon.2023.e17582
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