Case report: biallelic DNMT3A mutations in acute myeloid leukemia

DNMT3A gene mutations, detected in 20-25% of de novo acute myeloid leukemia (AML) patients, are typically heterozygous. Biallelic variants are uncommon, affecting ~3% of cases and identifying a worse prognosis. Indeed, two concomitant DNMT3A mutations were recently associated with shorter event-free...

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Detalles Bibliográficos
Autores principales: Cumbo, Cosimo, Orsini, Paola, Anelli, Luisa, Zagaria, Antonella, Iannò, Maria Federica, De Cecco, Loris, Minervini, Crescenzio Francesco, Coccaro, Nicoletta, Tota, Giuseppina, Parciante, Elisa, Conserva, Maria Rosa, Redavid, Immacolata, Tarantini, Francesco, Minervini, Angela, Carluccio, Paola, De Grassi, Anna, Pierri, Ciro Leonardo, Specchia, Giorgina, Musto, Pellegrino, Albano, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336536/
https://www.ncbi.nlm.nih.gov/pubmed/37448520
http://dx.doi.org/10.3389/fonc.2023.1205220

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