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Genetically detoxified tetanus toxin as a vaccine and conjugate carrier protein
Tetanus toxoid (TTxd), developed over 100 years ago, is a clinically effective, legacy vaccine against tetanus. Due to the extreme potency of native tetanus toxin, manufacturing and regulatory efforts often focus on TTxd production, standardization, and safety, rather than product modernization. Rec...
Autores principales: | Chang, Min-Ju, Ollivault-Shiflett, Morgane, Schuman, Richard, Nguyen, Son Ngoc, Kaltashov, Igor A., Bobst, Cedric, Rajagopal, Shalini P., Przedpelski, Amanda, Barbieri, Joseph T., Lees, Andrew |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336728/ https://www.ncbi.nlm.nih.gov/pubmed/35871872 http://dx.doi.org/10.1016/j.vaccine.2022.07.011 |
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