Cargando…

Can Simvastatin Reduce the Need for Immunomodulatory Drugs to Treat Uveitis?: A Prospective, Randomized, Placebo-Controlled Trial

OBJECTIVE: To assess the efficacy of simvastatin 80 mg/day versus placebo in patients with noninfectious nonanterior uveitis receiving prednisolone ≥ 10 mg/day. DESIGN: Randomized, double-masked, controlled trial. SUBJECTS: Adult patients with noninfectious nonanterior uveitis on oral prednisolone d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Janabi, Ahmed, Sharief, Lazha, Al Qassimi, Noura, Chen, Yi-Hsing, Ding, Tao, Ambler, Gareth, Ladas, Dimitris, Lightman, Sue, Tomkins-Netzer, Oren
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336795/ https://www.ncbi.nlm.nih.gov/pubmed/37449048 http://dx.doi.org/10.1016/j.xops.2023.100333

Ejemplares similares

Emerging Antibiotic Resistance Patterns Affect Visual Outcome Treating Acute Endophthalmitis
por: Wu, Xia-Ni, et al.
Publicado: (2022)

Ischemic Retinal Vasculitis and Its Management
por: Talat, Lazha, et al.
Publicado: (2014)

Role of Autofluorescence in Inflammatory/Infective Diseases of the Retina and Choroid
por: Samy, Ahmed, et al.
Publicado: (2014)

Difference in glaucoma progression between the first and second eye after consecutive bilateral glaucoma surgery in patients with bilateral uveitic glaucoma
por: Din, Norshamsiah Md, et al.
Publicado: (2016)

Examining the Choroid in Ocular Inflammation: A Focus on Enhanced Depth Imaging
por: Baltmr, Abeir, et al.
Publicado: (2014)

Vogt–Koyanagi–Harada syndrome – current perspectives
por: Baltmr, Abeir, et al.
Publicado: (2016)

A Meta-Analysis of Studies Evaluating Visual and Anatomical Outcomes in Patients with Treatment Resistant Neovascular Age-Related Macular Degeneration following Switching to Treatment with Aflibercept
por: Seguin-Greenstein, Sophie, et al.
Publicado: (2016)

Rhizobium radiobacter Endophthalmitis following Intravitreal Ranibizumab Injection
por: Joshi, Lavnish, et al.
Publicado: (2012)

Combined Infliximab and Rituximab in Necrotising Scleritis
por: Morarji, Jiten, et al.
Publicado: (2012)

Clinical Remission of Sight-Threatening Non-Infectious Uveitis Is Characterized by an Upregulation of Peripheral T-Regulatory Cell Polarized Towards T-bet and TIGIT
por: Gilbert, Rose M., et al.
Publicado: (2018)

Adhesion Molecule Targeted Therapy for Non-Infectious Uveitis
por: Chen, Yi-Hsing, et al.
Publicado: (2022)

Association between Vaccination with the BNT162b2 mRNA Coronavirus Disease 2019 Vaccine and Noninfectious Uveitis: A Population-Based Study
por: Tomkins-Netzer, Oren, et al.
Publicado: (2022)

Intravitreal bevacizumab injections for diabetic macular edema – predictors of response: a retrospective study
por: Joshi, Lavnish, et al.
Publicado: (2016)

Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis
por: Chen, Yi Hsing, et al.
Publicado: (2021)

A Review of Antimicrobial Therapy for Infectious Uveitis of the Posterior Segment
por: Sallam, Ahmed B, et al.
Publicado: (2018)

A Network of Serum Proteins Predict the Need for Systemic Immunomodulatory Therapy at Diagnosis in Noninfectious Uveitis
por: Kuiper, Jonas J.W., et al.
Publicado: (2022)

Polypoidal Choroidal Vasculopathy Complicating Retinal Laser in Quiescent Uveitis
por: Burke, Tomas R., et al.
Publicado: (2019)

A Review of the Landscape of Targeted Immunomodulatory Therapies for Non-Infectious Uveitis
por: Sharma, Srilakshmi M., et al.
Publicado: (2017)

Role of Multidrug Resistance Proteins in Nonresponders to Immunomodulatory Therapy for Noninfectious Uveitis
por: Tagirasa, Ravichandra, et al.
Publicado: (2020)

Immunomodulatory treatment and surgical management of idiopathic uveitis and juvenile idiopathic arthritis-associated uveitis in children: a French survey practice
por: Molimard, Julie, et al.
Publicado: (2021)

TORCH Particle Identification Algorithm for LHCb
por: Al Qassimi, Maryam
Publicado: (2016)

Simultaneous administration of fluoxetine and simvastatin ameliorates lipid profile, improves brain level of neurotransmitters, and increases bioavailability of simvastatin
por: Al-Asmari, Abdulrahman K, et al.
Publicado: (2017)

Efficacy and safety of immunomodulatory drugs in patients with anterior uveitis: A systematic literature review
por: Gómez-Gómez, Alejandro, et al.
Publicado: (2017)

Assessing the results of anophthalmic prostheses
por: Vardizer, Yoav, et al.
Publicado: (2021)

A Placebo-Controlled Trial of Simvastatin Therapy in Smith-Lemli-Opitz Syndrome
por: Wassif, Christopher A., et al.
Publicado: (2016)

Tuberculous Uveitis
por: Abu El-Asrar, Ahmed M., et al.
Publicado: (2009)

Antimetabolite Drugs Exhibit Distinctive Immunomodulatory Mechanisms and Effects on the Intestinal Microbiota in Experimental Autoimmune Uveitis
por: Llorenç, Victor, et al.
Publicado: (2022)

Pediatric Noninfectious Uveitis in a Tertiary Referral Center in Jordan: Clinical Spectrum and Immunomodulatory Treatment
por: Alzyoud, Raed, et al.
Publicado: (2022)

Cytomegalovirus anterior uveitis and occlusive retinal vasculitis without retinitis in a patient on immunomodulatory therapy
por: Fabozzi, Lorenzo, et al.
Publicado: (2023)

Polymorphisms of chemokine and chemokine receptor genes in idiopathic immune-mediated posterior segment uveitis
por: Ahad, Muhammad A., et al.
Publicado: (2007)

Respiratory Distress in Neonate With Scimitar Syndrome
por: Al Qasimi, Nabil, et al.
Publicado: (2020)

CD4(+) T-Cell Plasticity in Non-Infectious Retinal Inflammatory Disease
por: Chen, Yi-Hsing, et al.
Publicado: (2021)

Simvastatin and oxidative stress in humans: A randomized, double-blinded, placebo-controlled clinical trial
por: Rasmussen, Sanne Tofte, et al.
Publicado: (2016)

Post-marketing surveillance study of the safety of dexamethasone intravitreal implant in patients with retinal vein occlusion or noninfectious posterior segment uveitis
por: Tufail, Adnan, et al.
Publicado: (2018)

A Systematic Approach to Emergencies in Uveitis
por: Al-Dhibi, Hassan A., et al.
Publicado: (2014)

Unusual bilateral panuveitis uveitis with brucellosis
por: AlMutairi, Naif, et al.
Publicado: (2022)

Simvastatin Ameliorates Diabetic Cardiomyopathy by Attenuating Oxidative Stress and Inflammation in Rats
por: Al-Rasheed, Nawal M., et al.
Publicado: (2017)

Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3
por: Aktas, Erdem, et al.
Publicado: (2011)

Proof of Concept, Randomized, Placebo-Controlled Study of the Effect of Simvastatin on the Course of Age-Related Macular Degeneration
por: Guymer, Robyn H., et al.
Publicado: (2013)

A Prospective, Randomized, Placebo-Controlled Study of a Combination of Simvastatin and Chemotherapy in Metastatic Breast Cancer
por: Alarfi, Hiba, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ld75469p77hk7qe24er5ju08l5