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C- reactive protein levels in women with prelabour rupture of membrane and women with normal labour

BACKGROUND: There is a very little information known about CRP in term pregnancies. It is a marker that is easily tested and is inexpensive. Although CRP has been used very effectively in diagnosing infection in the neonate, its clinical use and values have not been studied in term pregnancies. The...

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Autores principales: Blossia, Susan, Tirkey, Richa Sasmita, Kingsbury, Beena, Yenuberi, Hilda, Mahasampath, Gowri, Jude, John, Benjamin, Santosh, Mathews, Jiji Elizabeth, Rathore, Swati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336935/
https://www.ncbi.nlm.nih.gov/pubmed/37448938
http://dx.doi.org/10.4103/jfmpc.jfmpc_1588_22
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author Blossia, Susan
Tirkey, Richa Sasmita
Kingsbury, Beena
Yenuberi, Hilda
Mahasampath, Gowri
Jude, John
Benjamin, Santosh
Mathews, Jiji Elizabeth
Rathore, Swati
author_facet Blossia, Susan
Tirkey, Richa Sasmita
Kingsbury, Beena
Yenuberi, Hilda
Mahasampath, Gowri
Jude, John
Benjamin, Santosh
Mathews, Jiji Elizabeth
Rathore, Swati
author_sort Blossia, Susan
collection PubMed
description BACKGROUND: There is a very little information known about CRP in term pregnancies. It is a marker that is easily tested and is inexpensive. Although CRP has been used very effectively in diagnosing infection in the neonate, its clinical use and values have not been studied in term pregnancies. The level of CRP that is truly normal or clinically innocuous is not known. OBJECTIVES: This is a cross-sectional study to compare the CRP levels in antenatal women with PROM and women with normal labor and assess its utility to predict sepsis. METHODS: This is a prospective study done over a period of one year and approved by the insititutional ethical committee (IRB. Min. No 11102[OBSERVE] dated 10.01.2018). Sample for CRP was collected from 112 antenatal women with prelabor rupture of membranes within 12 hours of admission (Group A) and from 112 antenatal women in spontaneous labor without rupture of membrane (Group B). CRP samples are processed by nephelometry method. RESULTS: The median CRP value in Group A is 9.15 and Group B is 7.26, with no statistical difference. Chorioamnionitis, neonatal sepsis, and endometritis were similar in both the groups. CONCLUSION: CRP cannot be used as predictor for chorioamnionitis, endometritis, and neonatal sepsis. There was no significant difference in CRP levels between the two groups.
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spelling pubmed-103369352023-07-13 C- reactive protein levels in women with prelabour rupture of membrane and women with normal labour Blossia, Susan Tirkey, Richa Sasmita Kingsbury, Beena Yenuberi, Hilda Mahasampath, Gowri Jude, John Benjamin, Santosh Mathews, Jiji Elizabeth Rathore, Swati J Family Med Prim Care Original Article BACKGROUND: There is a very little information known about CRP in term pregnancies. It is a marker that is easily tested and is inexpensive. Although CRP has been used very effectively in diagnosing infection in the neonate, its clinical use and values have not been studied in term pregnancies. The level of CRP that is truly normal or clinically innocuous is not known. OBJECTIVES: This is a cross-sectional study to compare the CRP levels in antenatal women with PROM and women with normal labor and assess its utility to predict sepsis. METHODS: This is a prospective study done over a period of one year and approved by the insititutional ethical committee (IRB. Min. No 11102[OBSERVE] dated 10.01.2018). Sample for CRP was collected from 112 antenatal women with prelabor rupture of membranes within 12 hours of admission (Group A) and from 112 antenatal women in spontaneous labor without rupture of membrane (Group B). CRP samples are processed by nephelometry method. RESULTS: The median CRP value in Group A is 9.15 and Group B is 7.26, with no statistical difference. Chorioamnionitis, neonatal sepsis, and endometritis were similar in both the groups. CONCLUSION: CRP cannot be used as predictor for chorioamnionitis, endometritis, and neonatal sepsis. There was no significant difference in CRP levels between the two groups. Wolters Kluwer - Medknow 2023-05 2023-05-31 /pmc/articles/PMC10336935/ /pubmed/37448938 http://dx.doi.org/10.4103/jfmpc.jfmpc_1588_22 Text en Copyright: © 2023 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Blossia, Susan
Tirkey, Richa Sasmita
Kingsbury, Beena
Yenuberi, Hilda
Mahasampath, Gowri
Jude, John
Benjamin, Santosh
Mathews, Jiji Elizabeth
Rathore, Swati
C- reactive protein levels in women with prelabour rupture of membrane and women with normal labour
title C- reactive protein levels in women with prelabour rupture of membrane and women with normal labour
title_full C- reactive protein levels in women with prelabour rupture of membrane and women with normal labour
title_fullStr C- reactive protein levels in women with prelabour rupture of membrane and women with normal labour
title_full_unstemmed C- reactive protein levels in women with prelabour rupture of membrane and women with normal labour
title_short C- reactive protein levels in women with prelabour rupture of membrane and women with normal labour
title_sort c- reactive protein levels in women with prelabour rupture of membrane and women with normal labour
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336935/
https://www.ncbi.nlm.nih.gov/pubmed/37448938
http://dx.doi.org/10.4103/jfmpc.jfmpc_1588_22
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