Rediscovering Cyanogen Gas for Organic Synthesis: Formation of 2-Cyanothiazole Derivatives

[Image: see text] The expeditious synthesis of an API building block, 2-cyanothiazole, from cyanogen gas and a readily available dithiane is reported. A previously undisclosed partially saturated intermediate is formed, which can be further functionalized and isolated by the acylation of the hydroxy...

Descripción completa

Detalles Bibliográficos
Autores principales: Prieschl, Michael, Sedelmeier, Joerg, Püntener, Kurt, Hildbrand, Stefan, Williams, Jason D., Kappe, C. Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337028/
https://www.ncbi.nlm.nih.gov/pubmed/37339330
http://dx.doi.org/10.1021/acs.joc.3c01110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337028/
https://www.ncbi.nlm.nih.gov/pubmed/37339330
http://dx.doi.org/10.1021/acs.joc.3c01110

Ejemplares similares