Visible-Light/Nickel-Catalyzed Carboxylation of C(sp(2)) Bromides via Formate Activation

[Image: see text] A new visible-light-driven method for the carboxylation of (hetero)aryl/vinyl bromides has been developed using catalytic 4CzIPN, nickel, phenyl triflimide, and sodium formate as a carboxylation agent. Interestingly, we found catalytic phenyl triflimide plays an essential role in p...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Gavin C., Zhang, Drason H., Zhang, Wanli, Soliven, Abigail H., Wuest, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337029/
https://www.ncbi.nlm.nih.gov/pubmed/37319431
http://dx.doi.org/10.1021/acs.joc.3c00895
Descripción
Sumario:[Image: see text] A new visible-light-driven method for the carboxylation of (hetero)aryl/vinyl bromides has been developed using catalytic 4CzIPN, nickel, phenyl triflimide, and sodium formate as a carboxylation agent. Interestingly, we found catalytic phenyl triflimide plays an essential role in promoting the reaction. While many C(sp(2)) carboxylation reactions require harsh reagents or gaseous carbon dioxide, we demonstrate the mild and facile construction of carboxylic acids from readily available starting materials.

Ejemplares similares