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Plasma and aqueous levels of subfatin, preptin and betatrophin in patients with diabetic retinopathy
AIM: To examine subfatin, preptin and betatrophin levels in plasma and aqueous in patients with diabetes mellitus (DM) (with and without retinopathy). MATERIAL AND METHOD: Sixty patients, who were similar in terms of age and gender, and were scheduled for operation due to cataract, were included in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337056/ https://www.ncbi.nlm.nih.gov/pubmed/37434133 http://dx.doi.org/10.1186/s12886-023-03075-0 |
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author | Güngör Kobat, Sabiha Gül, Fatih Cem Çelik, Fatih Liman Uzun, Seda Kobat, Mehmet Ali Akkoç, Ramazan Fazıl Aydın, Süleyman |
author_facet | Güngör Kobat, Sabiha Gül, Fatih Cem Çelik, Fatih Liman Uzun, Seda Kobat, Mehmet Ali Akkoç, Ramazan Fazıl Aydın, Süleyman |
author_sort | Güngör Kobat, Sabiha |
collection | PubMed |
description | AIM: To examine subfatin, preptin and betatrophin levels in plasma and aqueous in patients with diabetes mellitus (DM) (with and without retinopathy). MATERIAL AND METHOD: Sixty patients, who were similar in terms of age and gender, and were scheduled for operation due to cataract, were included in the study. The patients were divided into three groups as Group C (20 weeks without diabetes and comorbidity), Group DM (20 patients with DM but no retinopathy) and Group DR (20 patients with diabetic retinopathy). The preoperative body mass index (BMI), fasting plasma glucose, HbA1c, lipid profile levels of all patients in the groups were examined. Blood samples were also taken for plasma subfatin, preptin and betatrophin levels. At the beginning of the cataract surgery, 0.1 ml of aqueous fluid was taken from the anterior chamber. Plasma and aqueous subfatin, preptin and betatrophin levels were analyzed by ELISA (enzyme-linked immunosorbent assays) method. RESULTS: In our study results, there was a significant difference in BMI, fasting plasma glucose and hemoglobin A1c levels (p < 0.05 for all parameters). Plasma and aqueous subfatin levels were higher in Group DR compared to Group C (p < 0.001, p = 0.036, respectively). Plasma and aqueous preptin levels were higher in group DR and group DM than in group C (p = 0.001, p = 0.002, p < 0.001, p = 0.001, respectively). Plasma and aqueous betatrophin levels were higher in Group DR compared to group C (p = 0.001, p = 0.010, respectively). CONCLUSION: Subfatin, preptin and betatrophin molecules may have an important role in the pathogenesis of diabetic retinopathy. |
format | Online Article Text |
id | pubmed-10337056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-103370562023-07-13 Plasma and aqueous levels of subfatin, preptin and betatrophin in patients with diabetic retinopathy Güngör Kobat, Sabiha Gül, Fatih Cem Çelik, Fatih Liman Uzun, Seda Kobat, Mehmet Ali Akkoç, Ramazan Fazıl Aydın, Süleyman BMC Ophthalmol Research AIM: To examine subfatin, preptin and betatrophin levels in plasma and aqueous in patients with diabetes mellitus (DM) (with and without retinopathy). MATERIAL AND METHOD: Sixty patients, who were similar in terms of age and gender, and were scheduled for operation due to cataract, were included in the study. The patients were divided into three groups as Group C (20 weeks without diabetes and comorbidity), Group DM (20 patients with DM but no retinopathy) and Group DR (20 patients with diabetic retinopathy). The preoperative body mass index (BMI), fasting plasma glucose, HbA1c, lipid profile levels of all patients in the groups were examined. Blood samples were also taken for plasma subfatin, preptin and betatrophin levels. At the beginning of the cataract surgery, 0.1 ml of aqueous fluid was taken from the anterior chamber. Plasma and aqueous subfatin, preptin and betatrophin levels were analyzed by ELISA (enzyme-linked immunosorbent assays) method. RESULTS: In our study results, there was a significant difference in BMI, fasting plasma glucose and hemoglobin A1c levels (p < 0.05 for all parameters). Plasma and aqueous subfatin levels were higher in Group DR compared to Group C (p < 0.001, p = 0.036, respectively). Plasma and aqueous preptin levels were higher in group DR and group DM than in group C (p = 0.001, p = 0.002, p < 0.001, p = 0.001, respectively). Plasma and aqueous betatrophin levels were higher in Group DR compared to group C (p = 0.001, p = 0.010, respectively). CONCLUSION: Subfatin, preptin and betatrophin molecules may have an important role in the pathogenesis of diabetic retinopathy. BioMed Central 2023-07-11 /pmc/articles/PMC10337056/ /pubmed/37434133 http://dx.doi.org/10.1186/s12886-023-03075-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Güngör Kobat, Sabiha Gül, Fatih Cem Çelik, Fatih Liman Uzun, Seda Kobat, Mehmet Ali Akkoç, Ramazan Fazıl Aydın, Süleyman Plasma and aqueous levels of subfatin, preptin and betatrophin in patients with diabetic retinopathy |
title | Plasma and aqueous levels of subfatin, preptin and betatrophin in patients with diabetic retinopathy |
title_full | Plasma and aqueous levels of subfatin, preptin and betatrophin in patients with diabetic retinopathy |
title_fullStr | Plasma and aqueous levels of subfatin, preptin and betatrophin in patients with diabetic retinopathy |
title_full_unstemmed | Plasma and aqueous levels of subfatin, preptin and betatrophin in patients with diabetic retinopathy |
title_short | Plasma and aqueous levels of subfatin, preptin and betatrophin in patients with diabetic retinopathy |
title_sort | plasma and aqueous levels of subfatin, preptin and betatrophin in patients with diabetic retinopathy |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337056/ https://www.ncbi.nlm.nih.gov/pubmed/37434133 http://dx.doi.org/10.1186/s12886-023-03075-0 |
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