Spatially resolved transcriptomic profiles reveal unique defining molecular features of infiltrative 5ALA-metabolizing cells associated with glioblastoma recurrence

BACKGROUND: Spatiotemporal heterogeneity originating from genomic and transcriptional variation was found to contribute to subtype switching in isocitrate dehydrogenase-1 wild-type glioblastoma (GBM) prior to and upon recurrence. Fluorescence-guided neurosurgical resection utilizing 5-aminolevulinic...

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Detalles Bibliográficos
Autores principales: Andrieux, Geoffroy, Das, Tonmoy, Griffin, Michaela, Straehle, Jakob, Paine, Simon M. L., Beck, Jürgen, Boerries, Melanie, Heiland, Dieter H., Smith, Stuart J., Rahman, Ruman, Chakraborty, Sajib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337060/
https://www.ncbi.nlm.nih.gov/pubmed/37434262
http://dx.doi.org/10.1186/s13073-023-01207-1

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