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Development of the non-occupational post-exposure prophylaxis (NPEP) knowledge scale among Chinese men who have sex with men

BACKGROUND: Nonoccupational post-exposure prophylaxis (NPEP) is a short course of medication taken to reduce the likelihood of acquiring human immunodeficiency virus (HIV) infection upon exposure. A review of the literature demonstrates an urgent need for an empirically validated instrument that mea...

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Autores principales: Li, Haochu, Wei, Ran, Weinstein, Traci L., Kim, Eunsook, Jacques-Tiura, Angela J., Ning, Xiaofu, Ma, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337112/
https://www.ncbi.nlm.nih.gov/pubmed/37434141
http://dx.doi.org/10.1186/s12889-023-16206-5
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author Li, Haochu
Wei, Ran
Weinstein, Traci L.
Kim, Eunsook
Jacques-Tiura, Angela J.
Ning, Xiaofu
Ma, Wei
author_facet Li, Haochu
Wei, Ran
Weinstein, Traci L.
Kim, Eunsook
Jacques-Tiura, Angela J.
Ning, Xiaofu
Ma, Wei
author_sort Li, Haochu
collection PubMed
description BACKGROUND: Nonoccupational post-exposure prophylaxis (NPEP) is a short course of medication taken to reduce the likelihood of acquiring human immunodeficiency virus (HIV) infection upon exposure. A review of the literature demonstrates an urgent need for an empirically validated instrument that measures detailed knowledge of NPEP among the key population of men who have sex with men (MSM). METHODS: Semi-structured interviews, focus groups, and a cross-sectional survey with a sample of 419 MSM was conducted in 2018 in China to develop and psychometrically evaluate the new instrument, the NPEP Knowledge Scale. Exploratory and confirmatory factor analyses, differential item functioning analyses, and structural equation modeling were conducted using Mplus 7.4. RESULTS: The NPEP Knowledge Scale demonstrated excellent reliability and validity. Cronbach’s alpha was 0.903. The range of item R(2) were 0.527–0.969, p’s < 0.001. Model estimated inter-item correlations ranged between 0.534 and 0.968. In addition, HIV knowledge, NPEP use, and NPEP knowledge were all significantly correlated. CONCLUSIONS: The NPEP Knowledge Scale is suitable for research, program evaluation, and clinical and community services that require using NPEP to minimize the ever-present risk of new HIV infections. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-023-16206-5.
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spelling pubmed-103371122023-07-13 Development of the non-occupational post-exposure prophylaxis (NPEP) knowledge scale among Chinese men who have sex with men Li, Haochu Wei, Ran Weinstein, Traci L. Kim, Eunsook Jacques-Tiura, Angela J. Ning, Xiaofu Ma, Wei BMC Public Health Research BACKGROUND: Nonoccupational post-exposure prophylaxis (NPEP) is a short course of medication taken to reduce the likelihood of acquiring human immunodeficiency virus (HIV) infection upon exposure. A review of the literature demonstrates an urgent need for an empirically validated instrument that measures detailed knowledge of NPEP among the key population of men who have sex with men (MSM). METHODS: Semi-structured interviews, focus groups, and a cross-sectional survey with a sample of 419 MSM was conducted in 2018 in China to develop and psychometrically evaluate the new instrument, the NPEP Knowledge Scale. Exploratory and confirmatory factor analyses, differential item functioning analyses, and structural equation modeling were conducted using Mplus 7.4. RESULTS: The NPEP Knowledge Scale demonstrated excellent reliability and validity. Cronbach’s alpha was 0.903. The range of item R(2) were 0.527–0.969, p’s < 0.001. Model estimated inter-item correlations ranged between 0.534 and 0.968. In addition, HIV knowledge, NPEP use, and NPEP knowledge were all significantly correlated. CONCLUSIONS: The NPEP Knowledge Scale is suitable for research, program evaluation, and clinical and community services that require using NPEP to minimize the ever-present risk of new HIV infections. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-023-16206-5. BioMed Central 2023-07-11 /pmc/articles/PMC10337112/ /pubmed/37434141 http://dx.doi.org/10.1186/s12889-023-16206-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Li, Haochu
Wei, Ran
Weinstein, Traci L.
Kim, Eunsook
Jacques-Tiura, Angela J.
Ning, Xiaofu
Ma, Wei
Development of the non-occupational post-exposure prophylaxis (NPEP) knowledge scale among Chinese men who have sex with men
title Development of the non-occupational post-exposure prophylaxis (NPEP) knowledge scale among Chinese men who have sex with men
title_full Development of the non-occupational post-exposure prophylaxis (NPEP) knowledge scale among Chinese men who have sex with men
title_fullStr Development of the non-occupational post-exposure prophylaxis (NPEP) knowledge scale among Chinese men who have sex with men
title_full_unstemmed Development of the non-occupational post-exposure prophylaxis (NPEP) knowledge scale among Chinese men who have sex with men
title_short Development of the non-occupational post-exposure prophylaxis (NPEP) knowledge scale among Chinese men who have sex with men
title_sort development of the non-occupational post-exposure prophylaxis (npep) knowledge scale among chinese men who have sex with men
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337112/
https://www.ncbi.nlm.nih.gov/pubmed/37434141
http://dx.doi.org/10.1186/s12889-023-16206-5
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