Bruton’s tyrosine kinase inhibition reduces disease severity in a model of secondary progressive autoimmune demyelination

Bruton’s tyrosine kinase (BTK) is an emerging target in multiple sclerosis (MS). Alongside its role in B cell receptor signaling and B cell development, BTK regulates myeloid cell activation and inflammatory responses. Here we demonstrate efficacy of BTK inhibition in a model of secondary progressiv...

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Detalles Bibliográficos
Autores principales: Evonuk, Kirsten Scarlett, Wang, Sen, Mattie, Josh, Cracchiolo, C. J., Mager, Reine, Ferenčić, Željko, Sprague, Ethan, Carrier, Brandon, Schofield, Kai, Martinez, Evelyn, Stewart, Zachary, Petrosino, Tara, Johnson, Gregory Andrew, Yusuf, Isharat, Plaisted, Warren, Naiman, Zachary, Delp, Timothy, Carter, Laura, Marušić, Suzana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337138/
https://www.ncbi.nlm.nih.gov/pubmed/37438842
http://dx.doi.org/10.1186/s40478-023-01614-w

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