High glucose-upregulated PD-L1 expression through RAS signaling-driven downregulation of PTRH1 leads to suppression of T cell cytotoxic function in tumor environment

BACKGROUND: Nearly 80% of patients with pancreatic cancer suffer from glucose intolerance or diabetes. Pancreatic cancer complicated by diabetes has a more immunosuppressive tumor microenvironment (TME) and is associated with a worse prognosis. The relationship between glucose metabolism and program...

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Detalles Bibliográficos
Autores principales: Gao, Chenggang, Chen, Jiaoshun, Bai, Jianwei, Zhang, Haoxiang, Tao, Yanyi, Wu, Shihong, Li, Hehe, Wu, Heshui, Shen, Qiang, Yin, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337161/
https://www.ncbi.nlm.nih.gov/pubmed/37434177
http://dx.doi.org/10.1186/s12967-023-04302-4

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