Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy

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BACKGROUND: Acute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce immediate status epilepticus (SE), reactive gliosis, neurodegeneration, and epileptogenesis as a consequence. Medical countermeas...

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Detalles Bibliográficos
Autores principales: Vasanthi, Suraj S., Rao, Nikhil S., Samidurai, Manikandan, Massey, Nyzil, Meyer, Christina, Gage, Meghan, Kharate, Mihir, Almanza, Aida, Wachter, Logan, Mafuta, Candide, Trevino, Lily, Carlo, Adriana M., Bryant, Elijah, Corson, Brooke E., Wohlgemuth, Morgan, Ostrander, Morgan, Showman, Lucas, Wang, Chong, Thippeswamy, Thimmasettappa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337207/
https://www.ncbi.nlm.nih.gov/pubmed/37438764
http://dx.doi.org/10.1186/s12974-023-02847-1
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