Cargando…
The Triglyceride Glucose (TyG) Index as a Sensible Marker for Identifying Insulin Resistance and Predicting Diabetic Kidney Disease
BACKGROUND: Patients with insulin-resistant diabetes have the highest risk of kidney disease. The triglyceride glucose (TyG) index is considered a reliable and simple marker of insulin resistance. We studied the relationship between the TyG index, diabetic kidney disease (DKD), and related metabolic...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337482/ https://www.ncbi.nlm.nih.gov/pubmed/37421131 http://dx.doi.org/10.12659/MSM.939482 |
_version_ | 1785071434580623360 |
---|---|
author | Li, Hui Fang Miao, Xia Li, Ying |
author_facet | Li, Hui Fang Miao, Xia Li, Ying |
author_sort | Li, Hui Fang |
collection | PubMed |
description | BACKGROUND: Patients with insulin-resistant diabetes have the highest risk of kidney disease. The triglyceride glucose (TyG) index is considered a reliable and simple marker of insulin resistance. We studied the relationship between the TyG index, diabetic kidney disease (DKD), and related metabolic disorders in patients with type 2 diabetes. MATERIAL/METHODS: This retrospective study included a consecutive case series from January 2021 to October 2022 in the Department of Endocrinology at Hebei Yiling Hospital. In total, 673 patients with type 2 diabetes met the inclusion criteria. The TyG index was calculated by napierian logarithmic (ln) (fasting triglyceride×fasting glucose /2). Patient demographic and clinical indicators were obtained from medical records, and statistical analysis was conducted using SPSS version 23. RESULTS: The TyG index was significantly related to metabolic indicators (low-density lipoprotein, high-density lipoprotein, alanine aminotransferase, plasma albumin, serum uric acid, triglyceride, and fasting glucose) and urine albumin (P<0.01) but not with serum creatinine and estimated glomerular filtration rate. In multiple regression analysis, an increase in the TyG index was revealed to be an independent risk factor for DKD (OR: 1.699, P<0.001). CONCLUSIONS: The TyG index was independently related to DKD and related metabolic disorders; therefore, the TyG index can be used as an early sensitive target for clinical guidance in the treatment of DKD with insulin resistance. |
format | Online Article Text |
id | pubmed-10337482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103374822023-07-13 The Triglyceride Glucose (TyG) Index as a Sensible Marker for Identifying Insulin Resistance and Predicting Diabetic Kidney Disease Li, Hui Fang Miao, Xia Li, Ying Med Sci Monit Clinical Research BACKGROUND: Patients with insulin-resistant diabetes have the highest risk of kidney disease. The triglyceride glucose (TyG) index is considered a reliable and simple marker of insulin resistance. We studied the relationship between the TyG index, diabetic kidney disease (DKD), and related metabolic disorders in patients with type 2 diabetes. MATERIAL/METHODS: This retrospective study included a consecutive case series from January 2021 to October 2022 in the Department of Endocrinology at Hebei Yiling Hospital. In total, 673 patients with type 2 diabetes met the inclusion criteria. The TyG index was calculated by napierian logarithmic (ln) (fasting triglyceride×fasting glucose /2). Patient demographic and clinical indicators were obtained from medical records, and statistical analysis was conducted using SPSS version 23. RESULTS: The TyG index was significantly related to metabolic indicators (low-density lipoprotein, high-density lipoprotein, alanine aminotransferase, plasma albumin, serum uric acid, triglyceride, and fasting glucose) and urine albumin (P<0.01) but not with serum creatinine and estimated glomerular filtration rate. In multiple regression analysis, an increase in the TyG index was revealed to be an independent risk factor for DKD (OR: 1.699, P<0.001). CONCLUSIONS: The TyG index was independently related to DKD and related metabolic disorders; therefore, the TyG index can be used as an early sensitive target for clinical guidance in the treatment of DKD with insulin resistance. International Scientific Literature, Inc. 2023-07-08 /pmc/articles/PMC10337482/ /pubmed/37421131 http://dx.doi.org/10.12659/MSM.939482 Text en © Med Sci Monit, 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Clinical Research Li, Hui Fang Miao, Xia Li, Ying The Triglyceride Glucose (TyG) Index as a Sensible Marker for Identifying Insulin Resistance and Predicting Diabetic Kidney Disease |
title | The Triglyceride Glucose (TyG) Index as a Sensible Marker for Identifying Insulin Resistance and Predicting Diabetic Kidney Disease |
title_full | The Triglyceride Glucose (TyG) Index as a Sensible Marker for Identifying Insulin Resistance and Predicting Diabetic Kidney Disease |
title_fullStr | The Triglyceride Glucose (TyG) Index as a Sensible Marker for Identifying Insulin Resistance and Predicting Diabetic Kidney Disease |
title_full_unstemmed | The Triglyceride Glucose (TyG) Index as a Sensible Marker for Identifying Insulin Resistance and Predicting Diabetic Kidney Disease |
title_short | The Triglyceride Glucose (TyG) Index as a Sensible Marker for Identifying Insulin Resistance and Predicting Diabetic Kidney Disease |
title_sort | triglyceride glucose (tyg) index as a sensible marker for identifying insulin resistance and predicting diabetic kidney disease |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337482/ https://www.ncbi.nlm.nih.gov/pubmed/37421131 http://dx.doi.org/10.12659/MSM.939482 |
work_keys_str_mv | AT lihuifang thetriglycerideglucosetygindexasasensiblemarkerforidentifyinginsulinresistanceandpredictingdiabetickidneydisease AT miaoxia thetriglycerideglucosetygindexasasensiblemarkerforidentifyinginsulinresistanceandpredictingdiabetickidneydisease AT liying thetriglycerideglucosetygindexasasensiblemarkerforidentifyinginsulinresistanceandpredictingdiabetickidneydisease AT lihuifang triglycerideglucosetygindexasasensiblemarkerforidentifyinginsulinresistanceandpredictingdiabetickidneydisease AT miaoxia triglycerideglucosetygindexasasensiblemarkerforidentifyinginsulinresistanceandpredictingdiabetickidneydisease AT liying triglycerideglucosetygindexasasensiblemarkerforidentifyinginsulinresistanceandpredictingdiabetickidneydisease |