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REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA

Health care in Canada is delivered on a provincial or territorial level. The objective of our population-based study was to investigate regional differences in survival among Canadians diagnosed with central nervous system (CNS) tumours. We identified 50,670 patients diagnosed with a first-ever prim...

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Autores principales: Wu, Yifan, Yuan, Yan, Walker, Emily V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337533/
http://dx.doi.org/10.1093/noajnl/vdad071.035
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author Wu, Yifan
Yuan, Yan
Walker, Emily V
author_facet Wu, Yifan
Yuan, Yan
Walker, Emily V
author_sort Wu, Yifan
collection PubMed
description Health care in Canada is delivered on a provincial or territorial level. The objective of our population-based study was to investigate regional differences in survival among Canadians diagnosed with central nervous system (CNS) tumours. We identified 50,670 patients diagnosed with a first-ever primary CNS tumour between 2008 and 2017 with follow-up until December 31, 2017 (excluding Quebec) from the Canadian Cancer Registry linked to vital statistics. We selected the four highest incidence histologies and used Cox proportional hazards regression to estimate hazard ratios (HRs) for regions in Canada (British Columbia, the Prairie provinces, Ontario, the Atlantic provinces, and the Territories) adjusting for sex and tumour behaviour (malignant vs. non-malignant), and stratified by patient age. Ontario was the reference region and had the best survival profile for all histologies investigated. The Atlantic provinces had the highest HR for glioblastomas (HR=1.26, 95% CI:1.18-1.35), gliomas not otherwise specified (NOS) (Overall: HR=1.87, 95% CI:1.43-2.43; Pediatric population: HR=2.86, 95% CI:1.28-6.39) and unclassified tumours (HR=1.95, 95% CI:1.63-2.34). For meningiomas, the Territories had the highest HR (HR=2.44, 95% CI:1.09-5.45) followed by the Prairie provinces (HR=1.52, 95% CI:1.38-1.67). Our findings suggest that regional differences in survival may exist for patients with specific histological subtypes of CNS tumours at the population level. Whether the differential capture of non-malignant tumours across regions, tumour misclassification, or both contributes to the observed regional survival differences warrants further investigation.
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spelling pubmed-103375332023-07-13 REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA Wu, Yifan Yuan, Yan Walker, Emily V Neurooncol Adv Posters Health care in Canada is delivered on a provincial or territorial level. The objective of our population-based study was to investigate regional differences in survival among Canadians diagnosed with central nervous system (CNS) tumours. We identified 50,670 patients diagnosed with a first-ever primary CNS tumour between 2008 and 2017 with follow-up until December 31, 2017 (excluding Quebec) from the Canadian Cancer Registry linked to vital statistics. We selected the four highest incidence histologies and used Cox proportional hazards regression to estimate hazard ratios (HRs) for regions in Canada (British Columbia, the Prairie provinces, Ontario, the Atlantic provinces, and the Territories) adjusting for sex and tumour behaviour (malignant vs. non-malignant), and stratified by patient age. Ontario was the reference region and had the best survival profile for all histologies investigated. The Atlantic provinces had the highest HR for glioblastomas (HR=1.26, 95% CI:1.18-1.35), gliomas not otherwise specified (NOS) (Overall: HR=1.87, 95% CI:1.43-2.43; Pediatric population: HR=2.86, 95% CI:1.28-6.39) and unclassified tumours (HR=1.95, 95% CI:1.63-2.34). For meningiomas, the Territories had the highest HR (HR=2.44, 95% CI:1.09-5.45) followed by the Prairie provinces (HR=1.52, 95% CI:1.38-1.67). Our findings suggest that regional differences in survival may exist for patients with specific histological subtypes of CNS tumours at the population level. Whether the differential capture of non-malignant tumours across regions, tumour misclassification, or both contributes to the observed regional survival differences warrants further investigation. Oxford University Press 2023-07-12 /pmc/articles/PMC10337533/ http://dx.doi.org/10.1093/noajnl/vdad071.035 Text en © The Author(s) 2023. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Posters
Wu, Yifan
Yuan, Yan
Walker, Emily V
REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA
title REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA
title_full REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA
title_fullStr REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA
title_full_unstemmed REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA
title_short REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA
title_sort regional differences in the survival experience of patients with central nervous system tumours in canada
topic Posters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337533/
http://dx.doi.org/10.1093/noajnl/vdad071.035
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