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REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA
Health care in Canada is delivered on a provincial or territorial level. The objective of our population-based study was to investigate regional differences in survival among Canadians diagnosed with central nervous system (CNS) tumours. We identified 50,670 patients diagnosed with a first-ever prim...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337533/ http://dx.doi.org/10.1093/noajnl/vdad071.035 |
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author | Wu, Yifan Yuan, Yan Walker, Emily V |
author_facet | Wu, Yifan Yuan, Yan Walker, Emily V |
author_sort | Wu, Yifan |
collection | PubMed |
description | Health care in Canada is delivered on a provincial or territorial level. The objective of our population-based study was to investigate regional differences in survival among Canadians diagnosed with central nervous system (CNS) tumours. We identified 50,670 patients diagnosed with a first-ever primary CNS tumour between 2008 and 2017 with follow-up until December 31, 2017 (excluding Quebec) from the Canadian Cancer Registry linked to vital statistics. We selected the four highest incidence histologies and used Cox proportional hazards regression to estimate hazard ratios (HRs) for regions in Canada (British Columbia, the Prairie provinces, Ontario, the Atlantic provinces, and the Territories) adjusting for sex and tumour behaviour (malignant vs. non-malignant), and stratified by patient age. Ontario was the reference region and had the best survival profile for all histologies investigated. The Atlantic provinces had the highest HR for glioblastomas (HR=1.26, 95% CI:1.18-1.35), gliomas not otherwise specified (NOS) (Overall: HR=1.87, 95% CI:1.43-2.43; Pediatric population: HR=2.86, 95% CI:1.28-6.39) and unclassified tumours (HR=1.95, 95% CI:1.63-2.34). For meningiomas, the Territories had the highest HR (HR=2.44, 95% CI:1.09-5.45) followed by the Prairie provinces (HR=1.52, 95% CI:1.38-1.67). Our findings suggest that regional differences in survival may exist for patients with specific histological subtypes of CNS tumours at the population level. Whether the differential capture of non-malignant tumours across regions, tumour misclassification, or both contributes to the observed regional survival differences warrants further investigation. |
format | Online Article Text |
id | pubmed-10337533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-103375332023-07-13 REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA Wu, Yifan Yuan, Yan Walker, Emily V Neurooncol Adv Posters Health care in Canada is delivered on a provincial or territorial level. The objective of our population-based study was to investigate regional differences in survival among Canadians diagnosed with central nervous system (CNS) tumours. We identified 50,670 patients diagnosed with a first-ever primary CNS tumour between 2008 and 2017 with follow-up until December 31, 2017 (excluding Quebec) from the Canadian Cancer Registry linked to vital statistics. We selected the four highest incidence histologies and used Cox proportional hazards regression to estimate hazard ratios (HRs) for regions in Canada (British Columbia, the Prairie provinces, Ontario, the Atlantic provinces, and the Territories) adjusting for sex and tumour behaviour (malignant vs. non-malignant), and stratified by patient age. Ontario was the reference region and had the best survival profile for all histologies investigated. The Atlantic provinces had the highest HR for glioblastomas (HR=1.26, 95% CI:1.18-1.35), gliomas not otherwise specified (NOS) (Overall: HR=1.87, 95% CI:1.43-2.43; Pediatric population: HR=2.86, 95% CI:1.28-6.39) and unclassified tumours (HR=1.95, 95% CI:1.63-2.34). For meningiomas, the Territories had the highest HR (HR=2.44, 95% CI:1.09-5.45) followed by the Prairie provinces (HR=1.52, 95% CI:1.38-1.67). Our findings suggest that regional differences in survival may exist for patients with specific histological subtypes of CNS tumours at the population level. Whether the differential capture of non-malignant tumours across regions, tumour misclassification, or both contributes to the observed regional survival differences warrants further investigation. Oxford University Press 2023-07-12 /pmc/articles/PMC10337533/ http://dx.doi.org/10.1093/noajnl/vdad071.035 Text en © The Author(s) 2023. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Posters Wu, Yifan Yuan, Yan Walker, Emily V REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA |
title | REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA |
title_full | REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA |
title_fullStr | REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA |
title_full_unstemmed | REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA |
title_short | REGIONAL DIFFERENCES IN THE SURVIVAL EXPERIENCE OF PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMOURS IN CANADA |
title_sort | regional differences in the survival experience of patients with central nervous system tumours in canada |
topic | Posters |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337533/ http://dx.doi.org/10.1093/noajnl/vdad071.035 |
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