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A focus on sustainable method development for greener synthesis
Given the current global climate and health challenges, sustainability and cost-effectiveness are becoming unavoidable factors that must be considered in the development of new synthetic methodologies. In a recent publication, Kavthe et al. (R. D. Kavthe, K. S. Iyer, J. C. Caravez and B. H. Lipshutz...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337756/ https://www.ncbi.nlm.nih.gov/pubmed/37449072 http://dx.doi.org/10.1039/d3sc90120c |
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author | Tyler, Jasper L. Katzenburg, Felix Glorius, Frank |
author_facet | Tyler, Jasper L. Katzenburg, Felix Glorius, Frank |
author_sort | Tyler, Jasper L. |
collection | PubMed |
description | Given the current global climate and health challenges, sustainability and cost-effectiveness are becoming unavoidable factors that must be considered in the development of new synthetic methodologies. In a recent publication, Kavthe et al. (R. D. Kavthe, K. S. Iyer, J. C. Caravez and B. H. Lipshutz, Chem. Sci., 2023, 14, 6399, https://doi.org/10.1039/D3SC01699D) have succinctly demonstrated how employing more sustainable methodology can vastly reduce the environmental impact associated with the synthesis of the antimalarial drug candidate MMV688533. The most notable feature of this newly reported synthetic route is the application of aqueous micellar conditions to two Sonogashira coupling reactions that simultaneously improve the yield, catalyst loading and sustainability of these key steps. |
format | Online Article Text |
id | pubmed-10337756 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-103377562023-07-13 A focus on sustainable method development for greener synthesis Tyler, Jasper L. Katzenburg, Felix Glorius, Frank Chem Sci Chemistry Given the current global climate and health challenges, sustainability and cost-effectiveness are becoming unavoidable factors that must be considered in the development of new synthetic methodologies. In a recent publication, Kavthe et al. (R. D. Kavthe, K. S. Iyer, J. C. Caravez and B. H. Lipshutz, Chem. Sci., 2023, 14, 6399, https://doi.org/10.1039/D3SC01699D) have succinctly demonstrated how employing more sustainable methodology can vastly reduce the environmental impact associated with the synthesis of the antimalarial drug candidate MMV688533. The most notable feature of this newly reported synthetic route is the application of aqueous micellar conditions to two Sonogashira coupling reactions that simultaneously improve the yield, catalyst loading and sustainability of these key steps. The Royal Society of Chemistry 2023-06-29 /pmc/articles/PMC10337756/ /pubmed/37449072 http://dx.doi.org/10.1039/d3sc90120c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Tyler, Jasper L. Katzenburg, Felix Glorius, Frank A focus on sustainable method development for greener synthesis |
title | A focus on sustainable method development for greener synthesis |
title_full | A focus on sustainable method development for greener synthesis |
title_fullStr | A focus on sustainable method development for greener synthesis |
title_full_unstemmed | A focus on sustainable method development for greener synthesis |
title_short | A focus on sustainable method development for greener synthesis |
title_sort | focus on sustainable method development for greener synthesis |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337756/ https://www.ncbi.nlm.nih.gov/pubmed/37449072 http://dx.doi.org/10.1039/d3sc90120c |
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