Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism

Knowledge of protein dynamics is fundamental to the understanding of biological processes, with NMR and 2D-IR spectroscopy being two of the principal methods for studying protein dynamics. Here, we combine these two methods to gain a new understanding of the complex mechanism of a cytokine:receptor...

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Detalles Bibliográficos
Autores principales: Shaw, Daniel J., Waters, Lorna C., Strong, Sarah L., Schulze, Monika-Sarah E. D., Greetham, Gregory M., Towrie, Mike, Parker, Anthony W., Prosser, Christine E., Henry, Alistair J., Lawson, Alastair D. G., Carr, Mark. D., Taylor, Richard J., Hunt, Neil T., Muskett, Frederick W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337760/
https://www.ncbi.nlm.nih.gov/pubmed/37449080
http://dx.doi.org/10.1039/d3sc00728f

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