The Role of Müller Cells in Diabetic Macular Edema

Diabetic macular edema (DME) is a common complication of diabetic retinopathy and is the leading cause of vision loss in diabetic patients. Various factors, such as metabolic disorders and inflammation caused by hyperglycemia, are involved in the occurrence and development of DME, but the specific m...

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Detalles Bibliográficos
Autores principales: Lai, Dongwei, Wu, Yang, Shao, Chuhan, Qiu, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337800/
https://www.ncbi.nlm.nih.gov/pubmed/37418272
http://dx.doi.org/10.1167/iovs.64.10.8
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author Lai, Dongwei
Wu, Yang
Shao, Chuhan
Qiu, Qinghua
author_facet Lai, Dongwei
Wu, Yang
Shao, Chuhan
Qiu, Qinghua
author_sort Lai, Dongwei
collection PubMed
description Diabetic macular edema (DME) is a common complication of diabetic retinopathy and is the leading cause of vision loss in diabetic patients. Various factors, such as metabolic disorders and inflammation caused by hyperglycemia, are involved in the occurrence and development of DME, but the specific mechanism is still unclear. Müller cells are a type of macroglial cell unique to the fundus, distributed throughout the retina, and they play a unique role in retinal homeostasis. This article reviews the role of Müller cells in the pathological process of DME and the research progress in the treatment of DME by targeting Müller cells through gene therapy.
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spelling pubmed-103378002023-07-13 The Role of Müller Cells in Diabetic Macular Edema Lai, Dongwei Wu, Yang Shao, Chuhan Qiu, Qinghua Invest Ophthalmol Vis Sci Review Diabetic macular edema (DME) is a common complication of diabetic retinopathy and is the leading cause of vision loss in diabetic patients. Various factors, such as metabolic disorders and inflammation caused by hyperglycemia, are involved in the occurrence and development of DME, but the specific mechanism is still unclear. Müller cells are a type of macroglial cell unique to the fundus, distributed throughout the retina, and they play a unique role in retinal homeostasis. This article reviews the role of Müller cells in the pathological process of DME and the research progress in the treatment of DME by targeting Müller cells through gene therapy. The Association for Research in Vision and Ophthalmology 2023-07-07 /pmc/articles/PMC10337800/ /pubmed/37418272 http://dx.doi.org/10.1167/iovs.64.10.8 Text en Copyright 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Review
Lai, Dongwei
Wu, Yang
Shao, Chuhan
Qiu, Qinghua
The Role of Müller Cells in Diabetic Macular Edema
title The Role of Müller Cells in Diabetic Macular Edema
title_full The Role of Müller Cells in Diabetic Macular Edema
title_fullStr The Role of Müller Cells in Diabetic Macular Edema
title_full_unstemmed The Role of Müller Cells in Diabetic Macular Edema
title_short The Role of Müller Cells in Diabetic Macular Edema
title_sort role of müller cells in diabetic macular edema
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337800/
https://www.ncbi.nlm.nih.gov/pubmed/37418272
http://dx.doi.org/10.1167/iovs.64.10.8
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