Encephalitis and poor neuronal death-mediated control of herpes simplex virus in human inherited RIPK3 deficiency

Inborn errors of TLR3-dependent type I IFN immunity in cortical neurons underlie forebrain herpes simplex virus-1 (HSV-1) encephalitis (HSE) due to uncontrolled viral growth and subsequent cell death. We report an otherwise healthy patient with HSE who was compound heterozygous for nonsense (R422*)...

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Detalles Bibliográficos
Autores principales: Liu, Zhiyong, Garcia Reino, Eduardo J., Harschnitz, Oliver, Guo, Hongyan, Chan, Yi-Hao, Khobrekar, Noopur, Hasek, Mary L., Dobbs, Kerry, Rinchai, Darawan, Materna, Marie, Matuozzo, Daniela, Lee, Danyel, Bastard, Paul, Chen, Jie, Lee, Yoon Seung, Kim, Seong K., Zhao, Shuxiang, Amin, Param, Lorenzo, Lazaro, Seeleuthner, Yoann, Chevalier, Remi, Mazzola, Laure, Gay, Claire, Stephan, Jean-Louis, Milisavljevic, Baptiste, Boucherit, Soraya, Rozenberg, Flore, Perez de Diego, Rebeca, Dix, Richard D., Marr, Nico, Béziat, Vivien, Cobat, Aurelie, Aubart, Mélodie, Abel, Laurent, Chabrier, Stephane, Smith, Gregory A., Notarangelo, Luigi D., Mocarski, Edward S., Studer, Lorenz, Casanova, Jean-Laurent, Zhang, Shen-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337828/
https://www.ncbi.nlm.nih.gov/pubmed/37083451
http://dx.doi.org/10.1126/sciimmunol.ade2860

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