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Evidence and clinical relevance of maternal-fetal cardiac coupling: A scoping review
BACKGROUND: Researchers have long suspected a mutual interaction between maternal and fetal heart rhythms, referred to as maternal-fetal cardiac coupling (MFCC). While several studies have been published on this phenomenon, they vary in terms of methodologies, populations assessed, and definitions o...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337870/ https://www.ncbi.nlm.nih.gov/pubmed/37437012 http://dx.doi.org/10.1371/journal.pone.0287245 |
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author | Nichting, Thomas J. Bester, Maretha Joshi, Rohan Mischi, Massimo van der Ven, Myrthe van der Woude, Daisy A. A. Oei, S. Guid van Laar, Judith O. E. H. Vullings, Rik |
author_facet | Nichting, Thomas J. Bester, Maretha Joshi, Rohan Mischi, Massimo van der Ven, Myrthe van der Woude, Daisy A. A. Oei, S. Guid van Laar, Judith O. E. H. Vullings, Rik |
author_sort | Nichting, Thomas J. |
collection | PubMed |
description | BACKGROUND: Researchers have long suspected a mutual interaction between maternal and fetal heart rhythms, referred to as maternal-fetal cardiac coupling (MFCC). While several studies have been published on this phenomenon, they vary in terms of methodologies, populations assessed, and definitions of coupling. Moreover, a clear discussion of the potential clinical implications is often lacking. Subsequently, we perform a scoping review to map the current state of the research in this field and, by doing so, form a foundation for future clinically oriented research on this topic. METHODS: A literature search was performed in PubMed, Embase, and Cochrane. Filters were only set for language (English, Dutch, and German literature were included) and not for year of publication. After screening for the title and the abstract, a full-text evaluation of eligibility followed. All studies on MFCC were included which described coupling between heart rate measurements in both the mother and fetus, regardless of the coupling method used, gestational age, or the maternal or fetal health condition. RESULTS: 23 studies remained after a systematic evaluation of 6,672 studies. Of these, 21 studies found at least occasional instances of MFCC. Methods used to capture MFCC are synchrograms and corresponding phase coherence indices, cross-correlation, joint symbolic dynamics, transfer entropy, bivariate phase rectified signal averaging, and deep coherence. Physiological pathways regulating MFCC are suggested to exist either via the autonomic nervous system or due to the vibroacoustic effect, though neither of these suggested pathways has been verified. The strength and direction of MFCC are found to change with gestational age and with the rate of maternal breathing, while also being further altered in fetuses with cardiac abnormalities and during labor. CONCLUSION: From the synthesis of the available literature on MFCC presented in this scoping review, it seems evident that MFCC does indeed exist and may have clinical relevance in tracking fetal well-being and development during pregnancy. |
format | Online Article Text |
id | pubmed-10337870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-103378702023-07-13 Evidence and clinical relevance of maternal-fetal cardiac coupling: A scoping review Nichting, Thomas J. Bester, Maretha Joshi, Rohan Mischi, Massimo van der Ven, Myrthe van der Woude, Daisy A. A. Oei, S. Guid van Laar, Judith O. E. H. Vullings, Rik PLoS One Research Article BACKGROUND: Researchers have long suspected a mutual interaction between maternal and fetal heart rhythms, referred to as maternal-fetal cardiac coupling (MFCC). While several studies have been published on this phenomenon, they vary in terms of methodologies, populations assessed, and definitions of coupling. Moreover, a clear discussion of the potential clinical implications is often lacking. Subsequently, we perform a scoping review to map the current state of the research in this field and, by doing so, form a foundation for future clinically oriented research on this topic. METHODS: A literature search was performed in PubMed, Embase, and Cochrane. Filters were only set for language (English, Dutch, and German literature were included) and not for year of publication. After screening for the title and the abstract, a full-text evaluation of eligibility followed. All studies on MFCC were included which described coupling between heart rate measurements in both the mother and fetus, regardless of the coupling method used, gestational age, or the maternal or fetal health condition. RESULTS: 23 studies remained after a systematic evaluation of 6,672 studies. Of these, 21 studies found at least occasional instances of MFCC. Methods used to capture MFCC are synchrograms and corresponding phase coherence indices, cross-correlation, joint symbolic dynamics, transfer entropy, bivariate phase rectified signal averaging, and deep coherence. Physiological pathways regulating MFCC are suggested to exist either via the autonomic nervous system or due to the vibroacoustic effect, though neither of these suggested pathways has been verified. The strength and direction of MFCC are found to change with gestational age and with the rate of maternal breathing, while also being further altered in fetuses with cardiac abnormalities and during labor. CONCLUSION: From the synthesis of the available literature on MFCC presented in this scoping review, it seems evident that MFCC does indeed exist and may have clinical relevance in tracking fetal well-being and development during pregnancy. Public Library of Science 2023-07-12 /pmc/articles/PMC10337870/ /pubmed/37437012 http://dx.doi.org/10.1371/journal.pone.0287245 Text en © 2023 Nichting et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Nichting, Thomas J. Bester, Maretha Joshi, Rohan Mischi, Massimo van der Ven, Myrthe van der Woude, Daisy A. A. Oei, S. Guid van Laar, Judith O. E. H. Vullings, Rik Evidence and clinical relevance of maternal-fetal cardiac coupling: A scoping review |
title | Evidence and clinical relevance of maternal-fetal cardiac coupling: A scoping review |
title_full | Evidence and clinical relevance of maternal-fetal cardiac coupling: A scoping review |
title_fullStr | Evidence and clinical relevance of maternal-fetal cardiac coupling: A scoping review |
title_full_unstemmed | Evidence and clinical relevance of maternal-fetal cardiac coupling: A scoping review |
title_short | Evidence and clinical relevance of maternal-fetal cardiac coupling: A scoping review |
title_sort | evidence and clinical relevance of maternal-fetal cardiac coupling: a scoping review |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337870/ https://www.ncbi.nlm.nih.gov/pubmed/37437012 http://dx.doi.org/10.1371/journal.pone.0287245 |
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