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Corneal confocal microscopy demonstrates sensory nerve loss in children with autism spectrum disorder
Autism spectrum disorder (ASD) is a developmental disorder characterized by difficulty in communication and interaction with others. Postmortem studies have shown cerebral neuronal loss and neuroimaging studies show neuronal loss in the amygdala, cerebellum and inter-hemispheric regions of the brain...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337936/ https://www.ncbi.nlm.nih.gov/pubmed/37437060 http://dx.doi.org/10.1371/journal.pone.0288399 |
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author | Khan, Adnan Kamal, Madeeha Alhothi, Abdula Gad, Hoda Adan, Marian A. Ponirakis, Georgios Petropoulos, Ioannis N. Malik, Rayaz A. |
author_facet | Khan, Adnan Kamal, Madeeha Alhothi, Abdula Gad, Hoda Adan, Marian A. Ponirakis, Georgios Petropoulos, Ioannis N. Malik, Rayaz A. |
author_sort | Khan, Adnan |
collection | PubMed |
description | Autism spectrum disorder (ASD) is a developmental disorder characterized by difficulty in communication and interaction with others. Postmortem studies have shown cerebral neuronal loss and neuroimaging studies show neuronal loss in the amygdala, cerebellum and inter-hemispheric regions of the brain. Recent studies have shown altered tactile discrimination and allodynia on the face, mouth, hands and feet and intraepidermal nerve fiber loss in the legs of subjects with ASD. Fifteen children with ASD (age: 12.00 ± 3.55 years) and twenty age-matched healthy controls (age: 12.83 ± 1.91 years) underwent corneal confocal microscopy (CCM) and quantification of corneal nerve fiber morphology. Corneal nerve fibre density (fibers/mm(2)) (28.61 ± 5.74 vs. 40.42 ± 8.95, p = 0.000), corneal nerve fibre length (mm/mm(2)) (16.61 ± 3.26 vs. 21.44 ± 4.44, p = 0.001), corneal nerve branch density (branches/mm(2)) (43.68 ± 22.71 vs. 62.39 ± 21.58, p = 0.018) and corneal nerve fibre tortuosity (0.037 ± 0.023 vs. 0.074 ± 0.017, p = 0.000) were significantly lower and inferior whorl length (mm/mm(2)) (21.06 ± 6.12 vs. 23.43 ± 3.95, p = 0.255) was comparable in children with ASD compared to controls. CCM identifies central corneal nerve fiber loss in children with ASD. These findings, urge the need for larger longitudinal studies to determine the utility of CCM as an imaging biomarker for neuronal loss in different subtypes of ASD and in relation to disease progression. |
format | Online Article Text |
id | pubmed-10337936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-103379362023-07-13 Corneal confocal microscopy demonstrates sensory nerve loss in children with autism spectrum disorder Khan, Adnan Kamal, Madeeha Alhothi, Abdula Gad, Hoda Adan, Marian A. Ponirakis, Georgios Petropoulos, Ioannis N. Malik, Rayaz A. PLoS One Research Article Autism spectrum disorder (ASD) is a developmental disorder characterized by difficulty in communication and interaction with others. Postmortem studies have shown cerebral neuronal loss and neuroimaging studies show neuronal loss in the amygdala, cerebellum and inter-hemispheric regions of the brain. Recent studies have shown altered tactile discrimination and allodynia on the face, mouth, hands and feet and intraepidermal nerve fiber loss in the legs of subjects with ASD. Fifteen children with ASD (age: 12.00 ± 3.55 years) and twenty age-matched healthy controls (age: 12.83 ± 1.91 years) underwent corneal confocal microscopy (CCM) and quantification of corneal nerve fiber morphology. Corneal nerve fibre density (fibers/mm(2)) (28.61 ± 5.74 vs. 40.42 ± 8.95, p = 0.000), corneal nerve fibre length (mm/mm(2)) (16.61 ± 3.26 vs. 21.44 ± 4.44, p = 0.001), corneal nerve branch density (branches/mm(2)) (43.68 ± 22.71 vs. 62.39 ± 21.58, p = 0.018) and corneal nerve fibre tortuosity (0.037 ± 0.023 vs. 0.074 ± 0.017, p = 0.000) were significantly lower and inferior whorl length (mm/mm(2)) (21.06 ± 6.12 vs. 23.43 ± 3.95, p = 0.255) was comparable in children with ASD compared to controls. CCM identifies central corneal nerve fiber loss in children with ASD. These findings, urge the need for larger longitudinal studies to determine the utility of CCM as an imaging biomarker for neuronal loss in different subtypes of ASD and in relation to disease progression. Public Library of Science 2023-07-12 /pmc/articles/PMC10337936/ /pubmed/37437060 http://dx.doi.org/10.1371/journal.pone.0288399 Text en © 2023 Khan et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Khan, Adnan Kamal, Madeeha Alhothi, Abdula Gad, Hoda Adan, Marian A. Ponirakis, Georgios Petropoulos, Ioannis N. Malik, Rayaz A. Corneal confocal microscopy demonstrates sensory nerve loss in children with autism spectrum disorder |
title | Corneal confocal microscopy demonstrates sensory nerve loss in children with autism spectrum disorder |
title_full | Corneal confocal microscopy demonstrates sensory nerve loss in children with autism spectrum disorder |
title_fullStr | Corneal confocal microscopy demonstrates sensory nerve loss in children with autism spectrum disorder |
title_full_unstemmed | Corneal confocal microscopy demonstrates sensory nerve loss in children with autism spectrum disorder |
title_short | Corneal confocal microscopy demonstrates sensory nerve loss in children with autism spectrum disorder |
title_sort | corneal confocal microscopy demonstrates sensory nerve loss in children with autism spectrum disorder |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337936/ https://www.ncbi.nlm.nih.gov/pubmed/37437060 http://dx.doi.org/10.1371/journal.pone.0288399 |
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