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Leisure-time physical activity and gastric cancer risk: A pooled study within the Stomach cancer Pooling (StoP) Project

BACKGROUND: Although physical activity (PA) has been recognized as a favourable factor in the prevention of various diseases, including certain forms of cancer, the relationship between PA and gastric cancer (GC) is not yet fully understood. This study aims to provide data from a pooled analysis of...

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Autores principales: Mariani, Marco, Pastorino, Roberta, Pires Marafon, Denise, Johnson, Ken C., Hu, Jinfu, Molina de la Torre, Antonio Jose, Fernández-Tardón, Guillermo, Zaridze, David, Maximovich, Dmitry, Negri, Eva, La Vecchia, Carlo, Zhang, Zuo-Feng, Kurtz, Robert C., Pelucchi, Claudio, Rota, Matteo, Boccia, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337950/
https://www.ncbi.nlm.nih.gov/pubmed/37437057
http://dx.doi.org/10.1371/journal.pone.0286958
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author Mariani, Marco
Pastorino, Roberta
Pires Marafon, Denise
Johnson, Ken C.
Hu, Jinfu
Molina de la Torre, Antonio Jose
Fernández-Tardón, Guillermo
Zaridze, David
Maximovich, Dmitry
Negri, Eva
La Vecchia, Carlo
Zhang, Zuo-Feng
Kurtz, Robert C.
Pelucchi, Claudio
Rota, Matteo
Boccia, Stefania
author_facet Mariani, Marco
Pastorino, Roberta
Pires Marafon, Denise
Johnson, Ken C.
Hu, Jinfu
Molina de la Torre, Antonio Jose
Fernández-Tardón, Guillermo
Zaridze, David
Maximovich, Dmitry
Negri, Eva
La Vecchia, Carlo
Zhang, Zuo-Feng
Kurtz, Robert C.
Pelucchi, Claudio
Rota, Matteo
Boccia, Stefania
author_sort Mariani, Marco
collection PubMed
description BACKGROUND: Although physical activity (PA) has been recognized as a favourable factor in the prevention of various diseases, including certain forms of cancer, the relationship between PA and gastric cancer (GC) is not yet fully understood. This study aims to provide data from a pooled analysis of case-control studies within the Stomach cancer Pooling (StoP) Project to estimate the association between leisure-time PA and the occurrence of GC. METHODS: Six case-control studies from StoP project collected data on leisure-time PA, for a total of 2,343 cases and 8,614 controls. Subjects were classified into three leisure-time PA categories, either none/low, intermediate or high, based on study-specific tertiles. We used a two-stage approach. Firstly, we applied multivariable logistic regression models to obtain study-specific odds ratios (ORs) and corresponding 95% confidence intervals (CIs) then, we used a random-effect models to obtain pooled effect estimates. We performed stratified analyses according to demographic, lifestyle and clinical covariates. RESULTS: The meta-analysis showed ORs of GC with no significant differences between intermediate vs low and high vs low PA level (OR 1.05 [95%CI 0.76–1.45]; OR 1.23 [95%CI 0.78–1.94], respectively). GC risk estimates did not strongly differ across strata of selected covariates except for age ≤ 55 years old (high vs low level: OR 0.72 [95%CI 0.55–0.94]) and for control population-based studies (high vs low level: OR 0.79 [95%CI 0.68–0.93]). CONCLUSIONS: No association was found between leisure time PA and GC, apart from a slight suggestion of decreased risk below age 55 and in control population-based studies. These results may reflect specific characteristics of GC at a younger age, or the presence of a cohort effect mediating and interacting with socioeconomic determinants of GC The different distribution of PA levels among hospitalized controls could have led to an underestimated effect of PA on GC risk.
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spelling pubmed-103379502023-07-13 Leisure-time physical activity and gastric cancer risk: A pooled study within the Stomach cancer Pooling (StoP) Project Mariani, Marco Pastorino, Roberta Pires Marafon, Denise Johnson, Ken C. Hu, Jinfu Molina de la Torre, Antonio Jose Fernández-Tardón, Guillermo Zaridze, David Maximovich, Dmitry Negri, Eva La Vecchia, Carlo Zhang, Zuo-Feng Kurtz, Robert C. Pelucchi, Claudio Rota, Matteo Boccia, Stefania PLoS One Research Article BACKGROUND: Although physical activity (PA) has been recognized as a favourable factor in the prevention of various diseases, including certain forms of cancer, the relationship between PA and gastric cancer (GC) is not yet fully understood. This study aims to provide data from a pooled analysis of case-control studies within the Stomach cancer Pooling (StoP) Project to estimate the association between leisure-time PA and the occurrence of GC. METHODS: Six case-control studies from StoP project collected data on leisure-time PA, for a total of 2,343 cases and 8,614 controls. Subjects were classified into three leisure-time PA categories, either none/low, intermediate or high, based on study-specific tertiles. We used a two-stage approach. Firstly, we applied multivariable logistic regression models to obtain study-specific odds ratios (ORs) and corresponding 95% confidence intervals (CIs) then, we used a random-effect models to obtain pooled effect estimates. We performed stratified analyses according to demographic, lifestyle and clinical covariates. RESULTS: The meta-analysis showed ORs of GC with no significant differences between intermediate vs low and high vs low PA level (OR 1.05 [95%CI 0.76–1.45]; OR 1.23 [95%CI 0.78–1.94], respectively). GC risk estimates did not strongly differ across strata of selected covariates except for age ≤ 55 years old (high vs low level: OR 0.72 [95%CI 0.55–0.94]) and for control population-based studies (high vs low level: OR 0.79 [95%CI 0.68–0.93]). CONCLUSIONS: No association was found between leisure time PA and GC, apart from a slight suggestion of decreased risk below age 55 and in control population-based studies. These results may reflect specific characteristics of GC at a younger age, or the presence of a cohort effect mediating and interacting with socioeconomic determinants of GC The different distribution of PA levels among hospitalized controls could have led to an underestimated effect of PA on GC risk. Public Library of Science 2023-07-12 /pmc/articles/PMC10337950/ /pubmed/37437057 http://dx.doi.org/10.1371/journal.pone.0286958 Text en © 2023 Mariani et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mariani, Marco
Pastorino, Roberta
Pires Marafon, Denise
Johnson, Ken C.
Hu, Jinfu
Molina de la Torre, Antonio Jose
Fernández-Tardón, Guillermo
Zaridze, David
Maximovich, Dmitry
Negri, Eva
La Vecchia, Carlo
Zhang, Zuo-Feng
Kurtz, Robert C.
Pelucchi, Claudio
Rota, Matteo
Boccia, Stefania
Leisure-time physical activity and gastric cancer risk: A pooled study within the Stomach cancer Pooling (StoP) Project
title Leisure-time physical activity and gastric cancer risk: A pooled study within the Stomach cancer Pooling (StoP) Project
title_full Leisure-time physical activity and gastric cancer risk: A pooled study within the Stomach cancer Pooling (StoP) Project
title_fullStr Leisure-time physical activity and gastric cancer risk: A pooled study within the Stomach cancer Pooling (StoP) Project
title_full_unstemmed Leisure-time physical activity and gastric cancer risk: A pooled study within the Stomach cancer Pooling (StoP) Project
title_short Leisure-time physical activity and gastric cancer risk: A pooled study within the Stomach cancer Pooling (StoP) Project
title_sort leisure-time physical activity and gastric cancer risk: a pooled study within the stomach cancer pooling (stop) project
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337950/
https://www.ncbi.nlm.nih.gov/pubmed/37437057
http://dx.doi.org/10.1371/journal.pone.0286958
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