Challenges in treatment of gestational trophoblastic neoplasia in patients with MTHFR mutation: A case report

• We present a case of a patient with post molar pregnancy who has a MTHFR C677T mutation. • The mutation led to an alteration of recommended chemotherapy regimen. • No studies have reported treatment recommendations pertaining to gyn malignancies in patients with MTHFR allele. • We present a novel...

Descripción completa

Detalles Bibliográficos
Autores principales: Patel, Jharna M., Glassman, Danielle, Sayal, Sapna, Girda, Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Survey Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338143/
https://www.ncbi.nlm.nih.gov/pubmed/37449086
http://dx.doi.org/10.1016/j.gore.2023.101234
_version_ 1785071565359022080
author Patel, Jharna M.
Glassman, Danielle
Sayal, Sapna
Girda, Eugenia
author_facet Patel, Jharna M.
Glassman, Danielle
Sayal, Sapna
Girda, Eugenia
author_sort Patel, Jharna M.
collection PubMed
description • We present a case of a patient with post molar pregnancy who has a MTHFR C677T mutation. • The mutation led to an alteration of recommended chemotherapy regimen. • No studies have reported treatment recommendations pertaining to gyn malignancies in patients with MTHFR allele. • We present a novel instance where MTHFR mutation altered a patient’s treatment for gestational trophoblastic neoplasia.
format Online
Article
Text
id pubmed-10338143
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-103381432023-07-13 Challenges in treatment of gestational trophoblastic neoplasia in patients with MTHFR mutation: A case report Patel, Jharna M. Glassman, Danielle Sayal, Sapna Girda, Eugenia Gynecol Oncol Rep Survey Article • We present a case of a patient with post molar pregnancy who has a MTHFR C677T mutation. • The mutation led to an alteration of recommended chemotherapy regimen. • No studies have reported treatment recommendations pertaining to gyn malignancies in patients with MTHFR allele. • We present a novel instance where MTHFR mutation altered a patient’s treatment for gestational trophoblastic neoplasia. Elsevier 2023-06-29 /pmc/articles/PMC10338143/ /pubmed/37449086 http://dx.doi.org/10.1016/j.gore.2023.101234 Text en © 2023 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Survey Article
Patel, Jharna M.
Glassman, Danielle
Sayal, Sapna
Girda, Eugenia
Challenges in treatment of gestational trophoblastic neoplasia in patients with MTHFR mutation: A case report
title Challenges in treatment of gestational trophoblastic neoplasia in patients with MTHFR mutation: A case report
title_full Challenges in treatment of gestational trophoblastic neoplasia in patients with MTHFR mutation: A case report
title_fullStr Challenges in treatment of gestational trophoblastic neoplasia in patients with MTHFR mutation: A case report
title_full_unstemmed Challenges in treatment of gestational trophoblastic neoplasia in patients with MTHFR mutation: A case report
title_short Challenges in treatment of gestational trophoblastic neoplasia in patients with MTHFR mutation: A case report
title_sort challenges in treatment of gestational trophoblastic neoplasia in patients with mthfr mutation: a case report
topic Survey Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338143/
https://www.ncbi.nlm.nih.gov/pubmed/37449086
http://dx.doi.org/10.1016/j.gore.2023.101234
work_keys_str_mv AT pateljharnam challengesintreatmentofgestationaltrophoblasticneoplasiainpatientswithmthfrmutationacasereport
AT glassmandanielle challengesintreatmentofgestationaltrophoblasticneoplasiainpatientswithmthfrmutationacasereport
AT sayalsapna challengesintreatmentofgestationaltrophoblasticneoplasiainpatientswithmthfrmutationacasereport
AT girdaeugenia challengesintreatmentofgestationaltrophoblasticneoplasiainpatientswithmthfrmutationacasereport

Ejemplares similares