Principal component analysis of synaptic density measured with [(11)C]UCB-J PET in early Alzheimer’s disease

BACKGROUND: Synaptic loss is considered an early pathological event and major structural correlate of cognitive impairment in Alzheimer’s disease (AD). We used principal component analysis (PCA) to identify regional patterns of covariance in synaptic density using [(11)C]UCB-J PET and assessed the a...

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Detalles Bibliográficos
Autores principales: O'Dell, Ryan S., Higgins-Chen, Albert, Gupta, Dhruva, Chen, Ming-Kai, Naganawa, Mika, Toyonaga, Takuya, Lu, Yihuan, Ni, Gessica, Chupak, Anna, Zhao, Wenzhen, Salardini, Elaheh, Nabulsi, Nabeel B., Huang, Yiyun, Arnsten, Amy F.T., Carson, Richard E., van Dyck, Christopher H., Mecca, Adam P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338149/
https://www.ncbi.nlm.nih.gov/pubmed/37422964
http://dx.doi.org/10.1016/j.nicl.2023.103457

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