Cargando…

Seizures regulate the cation-Cl(−) cotransporter NKCC1 in a hamster model of epilepsy: implications for GABA neurotransmission

BACKGROUND: The balance between the activity of the Na(+)/K(+)/Cl(−) cotransporter (NKCC1) that introduces Cl(−) into the cell and the K(+)/Cl(−) cotransporter (KCC2) that transports Cl(−) outside the cell is critical in determining the inhibitory or excitatory outcome of GABA release. Mounting evid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bonet-Fernández, Juan-Manuel, Tranque, Pedro, Aroca-Aguilar, Jose Daniel, Muñoz, Luis J., López, Dolores E., Escribano, Julio, de Cabo, Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Neurology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338185/ https://www.ncbi.nlm.nih.gov/pubmed/37448751 http://dx.doi.org/10.3389/fneur.2023.1207616

Ejemplares similares

NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension
por: Orlov, Sergei N., et al.
Publicado: (2015)

Phosphorylation and Transport in the Na-K-2Cl Cotransporters, NKCC1 and NKCC2A, Compared in HEK-293 Cells
por: Hannemann, Anke, et al.
Publicado: (2011)

Membrane topology and function of the secretory Na+-K+-2Cl- cotransporter (NKCC1).
por: Gerelsaikhan, T, et al.
Publicado: (2000)

Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
por: Zhao, Yongxiang, et al.
Publicado: (2022)

Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders
por: Lam, Patricia, et al.
Publicado: (2023)

Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy
por: Yang, Xiaoyong, et al.
Publicado: (2020)

Prenatal Hypoxia Induces Cl(–) Cotransporters KCC2 and NKCC1 Developmental Abnormality and Disturbs the Influence of GABA(A) and Glycine Receptors on Fictive Breathing in a Newborn Rat
por: Caravagna, Céline, et al.
Publicado: (2022)

Author Correction: Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy
por: Yang, Xiaoyong, et al.
Publicado: (2020)

Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures
por: Puskarjov, Martin, et al.
Publicado: (2014)

Potassium Channel and NKCC Cotransporter Involvement in Ocular Refractive Control Mechanisms
por: Crewther, Sheila G., et al.
Publicado: (2008)

Novel Insights Regarding the Operational Characteristics and Teleological Purpose of the Renal Na(+)-K(+)-Cl(2) Cotransporter (NKCC2s) Splice Variants
por: Brunet, Geneviève M., et al.
Publicado: (2005)

The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2
por: Zhang, Sensen, et al.
Publicado: (2021)

TNFα induced up-regulation of Na(+),K(+),2Cl(−) cotransporter NKCC1 in hepatic ammonia clearance and cerebral ammonia toxicity
por: Pozdeev, Vitaly I., et al.
Publicado: (2017)

Expression of the sodium potassium chloride cotransporter (NKCC1) and sodium chloride cotransporter (NCC) and their effects on rat lens transparency
por: Chee, K.N., et al.
Publicado: (2010)

Functional Expression of the Na-K-2Cl Cotransporter NKCC2 in Mammalian Cells Fails to Confirm the Dominant-negative Effect of the AF Splice Variant
por: Hannemann, Anke, et al.
Publicado: (2009)

The Role of Na:K:2Cl Cotransporter 1 (NKCC1/SLC12A2) in Dental Epithelium during Enamel Formation in Mice
por: Jalali, Rozita, et al.
Publicado: (2017)

Gat1 (Gaba:Na(+):Cl(−)) Cotransport Function: Database Reconstruction with an Alternating Access Model
por: Hilgemann, Donald W., et al.
Publicado: (1999)

Modeling Glial Contributions to Seizures and Epileptogenesis: Cation-Chloride Cotransporters in Drosophila melanogaster
por: Rusan, Zeid M., et al.
Publicado: (2014)

cAMP Stimulates Apical Exocytosis of the Renal Na(+)-K(+)-2Cl(−) Cotransporter NKCC2 in the Thick Ascending Limb: ROLE OF PROTEIN KINASE A
por: Caceres, Paulo S., et al.
Publicado: (2009)

Correction: Modeling Glial Contributions to Seizures and Epileptogenesis: Cation-Chloride Cotransporters in Drosophila melanogaster
Publicado: (2014)

Modulation of brain cation-Cl(−) cotransport via the SPAK kinase inhibitor ZT-1a
por: Zhang, Jinwei, et al.
Publicado: (2020)

Limitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl(−) Transport
por: Khanna, Arjun, et al.
Publicado: (2013)

TGF-β/Smad3 Signalling Modulates GABA Neurotransmission: Implications in Parkinson’s Disease
por: Muñoz, Mª Dolores, et al.
Publicado: (2020)

Anxiety disorders and GABA neurotransmission: a disturbance of modulation
por: Nuss, Philippe
Publicado: (2015)

Astrocytic GABA transporter activity modulates excitatory neurotransmission
por: Boddum, Kim, et al.
Publicado: (2016)

Epilepsy and intellectual disability linked protein Shrm4 interaction with GABA(B)Rs shapes inhibitory neurotransmission
por: Zapata, Jonathan, et al.
Publicado: (2017)

Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures
por: Inceoglu, Bora, et al.
Publicado: (2013)

Gat1 (Gaba:Na(+):Cl(−)) Cotransport Function: Kinetic Studies in Giant Xenopus Oocyte Membrane Patches
por: Lu, Chin-Chih, et al.
Publicado: (1999)

Bumetanide, an Inhibitor of NKCC1 (Na-K-2Cl Cotransporter Isoform 1), Enhances Propofol-Induced Loss of Righting Reflex but Not Its Immobilizing Actions in Neonatal Rats
por: Koyama, Yukihide, et al.
Publicado: (2016)

A patient with multisystem dysfunction carries a truncation mutation in human SLC12A2, the gene encoding the Na-K-2Cl cotransporter, NKCC1
por: Delpire, Eric, et al.
Publicado: (2016)

New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: I. Role of GABA as a Modulator of Seizure Activity and Recently Approved Medications Acting on the GABA System
por: Perucca, Emilio, et al.
Publicado: (2023)

Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function
por: Liu, Ru, et al.
Publicado: (2020)

Gat1 (Gaba:Na(+):Cl(−)) Cotransport Function: Steady State Studies in Giant Xenopus Oocyte Membrane Patches
por: Lu, Chin-Chih, et al.
Publicado: (1999)

Pharmacotherapies Targeting GABA-Glutamate Neurotransmission for Treatment-Resistant Depression
por: Vecera, Courtney M., et al.
Publicado: (2023)

Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B
por: Hampel, Philip, et al.
Publicado: (2018)

NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility
por: Wang, Fushun, et al.
Publicado: (2016)

Functional kinomics establishes a critical node of volume-sensitive cation-Cl(−) cotransporter regulation in the mammalian brain
por: Zhang, Jinwei, et al.
Publicado: (2016)

Molecular mechanisms, physiological roles, and therapeutic implications of ion fluxes in bone cells: Emphasis on the cation‐Cl(−) cotransporters
por: Garneau, Alexandre P., et al.
Publicado: (2022)

Structural Pharmacology of Cation-Chloride Cotransporters
por: Zhao, Yongxiang, et al.
Publicado: (2022)

PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia
por: Jiang, Changyu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6jsrdmuvvc6i5tqaivgmi7jlf8