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Hydrochlorothiazide-induced glucose metabolism disorder is mediated by the gut microbiota via LPS-TLR4-related macrophage polarization

Hydrochlorothiazide (HCTZ) is reported to impair glucose tolerance and may induce new onset of diabetes, but the pharmacomicrobiomics of the adverse effect for HCTZ remains unknown. Mice-fed HCTZ exhibited insulin resistance and impaired glucose tolerance. By using FMT and antibiotic cocktail models...

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Detalles Bibliográficos
Autores principales:	Luo, Jian-Quan, Ren, Huan, Chen, Man-Yun, Zhao, Qing, Yang, Nian, Liu, Qian, Gao, Yong-Chao, Zhou, Hong-Hao, Huang, Wei-Hua, Zhang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338205/ https://www.ncbi.nlm.nih.gov/pubmed/37456847 http://dx.doi.org/10.1016/j.isci.2023.107130

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