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Differential effects of sugar and fat on adipose tissue inflammation
Obese individuals experience low grade inflammation initiated within their adipose tissue. However, the early events that lead to the release of these inflammatory factors from adipose tissue are poorly characterized. To separate glucose effects from lipid effects on adipose tissue, we used an adipo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338233/ https://www.ncbi.nlm.nih.gov/pubmed/37456843 http://dx.doi.org/10.1016/j.isci.2023.107163 |
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author | Avequin, Tracey Lau, Kin H. Waldhart, Althea N. Guak, Hannah Dykstra, Holly Krawczyk, Connie Wu, Ning |
author_facet | Avequin, Tracey Lau, Kin H. Waldhart, Althea N. Guak, Hannah Dykstra, Holly Krawczyk, Connie Wu, Ning |
author_sort | Avequin, Tracey |
collection | PubMed |
description | Obese individuals experience low grade inflammation initiated within their adipose tissue. However, the early events that lead to the release of these inflammatory factors from adipose tissue are poorly characterized. To separate glucose effects from lipid effects on adipose tissue, we used an adipose-specific TXNIP knockout model where excess basal glucose influx into adipocytes led to modest increase in adiposity without using high fat diet. We found an uncoupling of two events that are generally presumed to be coregulated: (1) an increase of adipose tissue macrophage (ATM) number; and (2) pro-inflammatory activation of ATMs. These two events are associated with different triggering signals: elevated free fatty acids output and extracellular matrix remodeling with increased ATM number, whereas decreased adiponectin level with activated ATM. This separation reflects non-overlapping pathways regulated by glucose and lipids in adipocytes, and neither group alone is sufficient to elicit the full inflammatory response in adipose tissue. |
format | Online Article Text |
id | pubmed-10338233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103382332023-07-14 Differential effects of sugar and fat on adipose tissue inflammation Avequin, Tracey Lau, Kin H. Waldhart, Althea N. Guak, Hannah Dykstra, Holly Krawczyk, Connie Wu, Ning iScience Article Obese individuals experience low grade inflammation initiated within their adipose tissue. However, the early events that lead to the release of these inflammatory factors from adipose tissue are poorly characterized. To separate glucose effects from lipid effects on adipose tissue, we used an adipose-specific TXNIP knockout model where excess basal glucose influx into adipocytes led to modest increase in adiposity without using high fat diet. We found an uncoupling of two events that are generally presumed to be coregulated: (1) an increase of adipose tissue macrophage (ATM) number; and (2) pro-inflammatory activation of ATMs. These two events are associated with different triggering signals: elevated free fatty acids output and extracellular matrix remodeling with increased ATM number, whereas decreased adiponectin level with activated ATM. This separation reflects non-overlapping pathways regulated by glucose and lipids in adipocytes, and neither group alone is sufficient to elicit the full inflammatory response in adipose tissue. Elsevier 2023-06-19 /pmc/articles/PMC10338233/ /pubmed/37456843 http://dx.doi.org/10.1016/j.isci.2023.107163 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Avequin, Tracey Lau, Kin H. Waldhart, Althea N. Guak, Hannah Dykstra, Holly Krawczyk, Connie Wu, Ning Differential effects of sugar and fat on adipose tissue inflammation |
title | Differential effects of sugar and fat on adipose tissue inflammation |
title_full | Differential effects of sugar and fat on adipose tissue inflammation |
title_fullStr | Differential effects of sugar and fat on adipose tissue inflammation |
title_full_unstemmed | Differential effects of sugar and fat on adipose tissue inflammation |
title_short | Differential effects of sugar and fat on adipose tissue inflammation |
title_sort | differential effects of sugar and fat on adipose tissue inflammation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338233/ https://www.ncbi.nlm.nih.gov/pubmed/37456843 http://dx.doi.org/10.1016/j.isci.2023.107163 |
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