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Differential effects of sugar and fat on adipose tissue inflammation

Obese individuals experience low grade inflammation initiated within their adipose tissue. However, the early events that lead to the release of these inflammatory factors from adipose tissue are poorly characterized. To separate glucose effects from lipid effects on adipose tissue, we used an adipo...

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Detalles Bibliográficos
Autores principales: Avequin, Tracey, Lau, Kin H., Waldhart, Althea N., Guak, Hannah, Dykstra, Holly, Krawczyk, Connie, Wu, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338233/
https://www.ncbi.nlm.nih.gov/pubmed/37456843
http://dx.doi.org/10.1016/j.isci.2023.107163
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author Avequin, Tracey
Lau, Kin H.
Waldhart, Althea N.
Guak, Hannah
Dykstra, Holly
Krawczyk, Connie
Wu, Ning
author_facet Avequin, Tracey
Lau, Kin H.
Waldhart, Althea N.
Guak, Hannah
Dykstra, Holly
Krawczyk, Connie
Wu, Ning
author_sort Avequin, Tracey
collection PubMed
description Obese individuals experience low grade inflammation initiated within their adipose tissue. However, the early events that lead to the release of these inflammatory factors from adipose tissue are poorly characterized. To separate glucose effects from lipid effects on adipose tissue, we used an adipose-specific TXNIP knockout model where excess basal glucose influx into adipocytes led to modest increase in adiposity without using high fat diet. We found an uncoupling of two events that are generally presumed to be coregulated: (1) an increase of adipose tissue macrophage (ATM) number; and (2) pro-inflammatory activation of ATMs. These two events are associated with different triggering signals: elevated free fatty acids output and extracellular matrix remodeling with increased ATM number, whereas decreased adiponectin level with activated ATM. This separation reflects non-overlapping pathways regulated by glucose and lipids in adipocytes, and neither group alone is sufficient to elicit the full inflammatory response in adipose tissue.
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spelling pubmed-103382332023-07-14 Differential effects of sugar and fat on adipose tissue inflammation Avequin, Tracey Lau, Kin H. Waldhart, Althea N. Guak, Hannah Dykstra, Holly Krawczyk, Connie Wu, Ning iScience Article Obese individuals experience low grade inflammation initiated within their adipose tissue. However, the early events that lead to the release of these inflammatory factors from adipose tissue are poorly characterized. To separate glucose effects from lipid effects on adipose tissue, we used an adipose-specific TXNIP knockout model where excess basal glucose influx into adipocytes led to modest increase in adiposity without using high fat diet. We found an uncoupling of two events that are generally presumed to be coregulated: (1) an increase of adipose tissue macrophage (ATM) number; and (2) pro-inflammatory activation of ATMs. These two events are associated with different triggering signals: elevated free fatty acids output and extracellular matrix remodeling with increased ATM number, whereas decreased adiponectin level with activated ATM. This separation reflects non-overlapping pathways regulated by glucose and lipids in adipocytes, and neither group alone is sufficient to elicit the full inflammatory response in adipose tissue. Elsevier 2023-06-19 /pmc/articles/PMC10338233/ /pubmed/37456843 http://dx.doi.org/10.1016/j.isci.2023.107163 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Avequin, Tracey
Lau, Kin H.
Waldhart, Althea N.
Guak, Hannah
Dykstra, Holly
Krawczyk, Connie
Wu, Ning
Differential effects of sugar and fat on adipose tissue inflammation
title Differential effects of sugar and fat on adipose tissue inflammation
title_full Differential effects of sugar and fat on adipose tissue inflammation
title_fullStr Differential effects of sugar and fat on adipose tissue inflammation
title_full_unstemmed Differential effects of sugar and fat on adipose tissue inflammation
title_short Differential effects of sugar and fat on adipose tissue inflammation
title_sort differential effects of sugar and fat on adipose tissue inflammation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338233/
https://www.ncbi.nlm.nih.gov/pubmed/37456843
http://dx.doi.org/10.1016/j.isci.2023.107163
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