Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload

Non-canonical Wnt signaling activated by Wnt5a/Wnt11 is required for the second heart field development in mice. However, the pathophysiological role of non-canonical Wnt signaling in the adult heart has not been fully elucidated. Here we show that cardiomyocyte-specific Wnt5a knockout mice exhibit...

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Detalles Bibliográficos
Autores principales: Kishimoto, Hiroshi, Iwasaki, Masayoshi, Wada, Kensaku, Horitani, Keita, Tsukamoto, Osamu, Kamikubo, Kenta, Nomura, Seitaro, Matsumoto, Shinji, Harada, Takeshi, Motooka, Daisuke, Okuzaki, Daisuke, Takashima, Seiji, Komuro, Issei, Kikuchi, Akira, Shiojima, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338234/
https://www.ncbi.nlm.nih.gov/pubmed/37456848
http://dx.doi.org/10.1016/j.isci.2023.107146

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