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CSL362 potently and specifically depletes pDCs invitro and ablates SLE-immune complex-induced IFN responses

Systemic lupus erythematosus (SLE) is an autoimmune disease with significant morbidity and mortality. Type I interferon (IFN) drives SLE pathology and plasmacytoid dendritic cells (pDCs) are potent producers of IFN; however, the specific effects of pDC depletion have not been demonstrated. We show C...

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Detalles Bibliográficos
Autores principales:	Monaghan, Katherine A., Hoi, Alberta, Gamell, Cristina, Tai, Tsin Yee, Linggi, Bryan, Jordan, Jarrat, Cesaroni, Matteo, Sato, Takahiro, Ng, Milica, Oon, Shereen, Benson, Jacqueline, Wicks, Ian, Morand, Eric, Wilson, Nicholas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338305/ https://www.ncbi.nlm.nih.gov/pubmed/37456846 http://dx.doi.org/10.1016/j.isci.2023.107173

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