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Downregulation of hepatic METTL3 contributes to APAP-induced liver injury in mice

BACKGROUND & AIMS: Acetaminophen (APAP) overdose is a major cause of acute liver failure in the Western world, but its molecular mechanisms are not fully understood. Methyltransferase-like 3 (METTL3) is a core N6-methyl-adenosine (m6A) RNA methyltransferase that has been shown to regulate many p...

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Detalles Bibliográficos
Autores principales:	Liu, Chunhong, Li, Xinzhi, Gao, Ming, Dong, Yanbin, Chen, Zheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338307/ https://www.ncbi.nlm.nih.gov/pubmed/37456679 http://dx.doi.org/10.1016/j.jhepr.2023.100766

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