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Functional and structural characterization of Streptococcus pneumoniae pyruvate kinase involved in fosfomycin resistance

Glycolysis is the primary metabolic pathway in the strictly fermentative Streptococcus pneumoniae, which is a major human pathogen associated with antibiotic resistance. Pyruvate kinase (PYK) is the last enzyme in this pathway that catalyzes the production of pyruvate from phosphoenolpyruvate (PEP)...

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Detalles Bibliográficos
Autores principales: Taguchi, Atsushi, Nakashima, Ryosuke, Nishino, Kunihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338316/
https://www.ncbi.nlm.nih.gov/pubmed/37286036
http://dx.doi.org/10.1016/j.jbc.2023.104892