Cytoskeletal disarray increases arrhythmogenic vulnerability during sympathetic stimulation in a model of hypertrophic cardiomyopathy

Familial hypertrophic cardiomyopathy (FHC) patients are advised to avoid strenuous exercise due to increased risk of arrhythmias. Mice expressing the human FHC-causing mutation R403Q in the myosin heavy chain gene (MYH6) recapitulate the human phenotype, including cytoskeletal disarray and increased...

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Detalles Bibliográficos
Autores principales: Cserne Szappanos, Henrietta, Viola, Helena M., Ito, Danica W., Lim, Seakcheng, Mangala, Melissa, Holliday, Mira, Barratt Ross, Samantha, Semsarian, Christopher, Hill, Adam, Dixon, Rose E., Hool, Livia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338442/
https://www.ncbi.nlm.nih.gov/pubmed/37438479
http://dx.doi.org/10.1038/s41598-023-38296-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338442/
https://www.ncbi.nlm.nih.gov/pubmed/37438479
http://dx.doi.org/10.1038/s41598-023-38296-2

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