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Adaptable control policies for variable liquid chromatography columns using deep reinforcement learning
Controlling chromatography systems for downstream processing of biotherapeutics is challenging because of the highly nonlinear behavior of feed components and complex interactions with binding phases. This challenge is exacerbated by the highly variable binding properties of the chromatography colum...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338460/ https://www.ncbi.nlm.nih.gov/pubmed/37438376 http://dx.doi.org/10.1038/s41598-023-38145-2 |