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Membranes prime the RapGEF EPAC1 to transduce cAMP signaling

EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal nanodomains challenged the current model of EPAC1 activation in the cytosol. Here, we discover t...

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Detalles Bibliográficos
Autores principales:	Sartre, Candice, Peurois, François, Ley, Marie, Kryszke, Marie-Hélène, Zhang, Wenhua, Courilleau, Delphine, Fischmeister, Rodolphe, Ambroise, Yves, Zeghouf, Mahel, Cianferani, Sarah, Ferrandez, Yann, Cherfils, Jacqueline
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338474/ https://www.ncbi.nlm.nih.gov/pubmed/37438343 http://dx.doi.org/10.1038/s41467-023-39894-4

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