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Mid-term symptomatic relief after platelet-rich plasma infiltration in vulvar lichen sclerosus

PURPOSE: Vulvar lichen sclerosus (LS) is a chronic, progressive, autoimmune dermatologic condition that causes cutaneous changes accompanied by pruritus and pain. There remains a small population with vulvar LS refractory to topical corticosteroids. Injection of platelet-rich plasma (PRP) has been r...

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Autores principales: Medina Garrido, Carola, Cano García, Alejandra, de la Cruz Cea, Lidia, Oreja Cuesta, Ana B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338614/
https://www.ncbi.nlm.nih.gov/pubmed/36656384
http://dx.doi.org/10.1007/s00403-023-02529-1
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author Medina Garrido, Carola
Cano García, Alejandra
de la Cruz Cea, Lidia
Oreja Cuesta, Ana B.
author_facet Medina Garrido, Carola
Cano García, Alejandra
de la Cruz Cea, Lidia
Oreja Cuesta, Ana B.
author_sort Medina Garrido, Carola
collection PubMed
description PURPOSE: Vulvar lichen sclerosus (LS) is a chronic, progressive, autoimmune dermatologic condition that causes cutaneous changes accompanied by pruritus and pain. There remains a small population with vulvar LS refractory to topical corticosteroids. Injection of platelet-rich plasma (PRP) has been reported to have positive effects on tissue repair. The aim of this pilot study was to evaluate changes in symptom scores during and after PRP vulvar infiltration. METHODS: Three PRP infiltrations were administered to 28 female postmenopausal patients with biopsy-proved LS with unsatisfactory response to steroid therapy. Change in score according to the Clinical Scoring System for Vulvar Lichen Sclerosus (CSS) was measured on six occasions over the course of a year. We used growth curve modeling to measure change over the period of the study. RESULTS: Women in our study experienced a statistically significant improvement in auto-assessed symptoms of vulvar lichen sclerosus, and this improvement appears to be maintained throughout the monitoring year. CONCLUSION: Platelet-rich plasma may have a role in symptom relief in certain cases of patients with LS that do not respond to first-line therapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00403-023-02529-1.
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spelling pubmed-103386142023-07-14 Mid-term symptomatic relief after platelet-rich plasma infiltration in vulvar lichen sclerosus Medina Garrido, Carola Cano García, Alejandra de la Cruz Cea, Lidia Oreja Cuesta, Ana B. Arch Dermatol Res Original Paper PURPOSE: Vulvar lichen sclerosus (LS) is a chronic, progressive, autoimmune dermatologic condition that causes cutaneous changes accompanied by pruritus and pain. There remains a small population with vulvar LS refractory to topical corticosteroids. Injection of platelet-rich plasma (PRP) has been reported to have positive effects on tissue repair. The aim of this pilot study was to evaluate changes in symptom scores during and after PRP vulvar infiltration. METHODS: Three PRP infiltrations were administered to 28 female postmenopausal patients with biopsy-proved LS with unsatisfactory response to steroid therapy. Change in score according to the Clinical Scoring System for Vulvar Lichen Sclerosus (CSS) was measured on six occasions over the course of a year. We used growth curve modeling to measure change over the period of the study. RESULTS: Women in our study experienced a statistically significant improvement in auto-assessed symptoms of vulvar lichen sclerosus, and this improvement appears to be maintained throughout the monitoring year. CONCLUSION: Platelet-rich plasma may have a role in symptom relief in certain cases of patients with LS that do not respond to first-line therapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00403-023-02529-1. Springer Berlin Heidelberg 2023-01-19 2023 /pmc/articles/PMC10338614/ /pubmed/36656384 http://dx.doi.org/10.1007/s00403-023-02529-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Medina Garrido, Carola
Cano García, Alejandra
de la Cruz Cea, Lidia
Oreja Cuesta, Ana B.
Mid-term symptomatic relief after platelet-rich plasma infiltration in vulvar lichen sclerosus
title Mid-term symptomatic relief after platelet-rich plasma infiltration in vulvar lichen sclerosus
title_full Mid-term symptomatic relief after platelet-rich plasma infiltration in vulvar lichen sclerosus
title_fullStr Mid-term symptomatic relief after platelet-rich plasma infiltration in vulvar lichen sclerosus
title_full_unstemmed Mid-term symptomatic relief after platelet-rich plasma infiltration in vulvar lichen sclerosus
title_short Mid-term symptomatic relief after platelet-rich plasma infiltration in vulvar lichen sclerosus
title_sort mid-term symptomatic relief after platelet-rich plasma infiltration in vulvar lichen sclerosus
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338614/
https://www.ncbi.nlm.nih.gov/pubmed/36656384
http://dx.doi.org/10.1007/s00403-023-02529-1
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