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Solubility of hesperidin drug in aqueous biodegradable acidic choline chloride-based deep eutectic solvents

Important efforts have been made over the past years to improve the drug acts, which leads to the discovery of novel drug preparations and delivery systems. The selection of suitable green solvents for novel drug discovery and drug delivery depends on a molecular-level understanding of the interacti...

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Autores principales: Shekaari, Hemayat, Zafarani-Moattar, Mohammed Taghi, Mokhtarpour, Masumeh, Faraji, Saeid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338632/
https://www.ncbi.nlm.nih.gov/pubmed/37438381
http://dx.doi.org/10.1038/s41598-023-38120-x
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author Shekaari, Hemayat
Zafarani-Moattar, Mohammed Taghi
Mokhtarpour, Masumeh
Faraji, Saeid
author_facet Shekaari, Hemayat
Zafarani-Moattar, Mohammed Taghi
Mokhtarpour, Masumeh
Faraji, Saeid
author_sort Shekaari, Hemayat
collection PubMed
description Important efforts have been made over the past years to improve the drug acts, which leads to the discovery of novel drug preparations and delivery systems. The selection of suitable green solvents for novel drug discovery and drug delivery depends on a molecular-level understanding of the interaction between drug molecules and the solvents. Deep eutectic solvents (DESs) are already used in sustainable extraction methods of natural products for their very high solvent power, high chemical and thermal stability, non-toxicity, and non-flammable. The thermodynamic investigation provides deep and complete knowledge of interactions and the choice of appropriate and suitable production compounds in pharmaceutical fields. Particularly, the analysis of drugs+DESs in aqueous media is a central issue in many types of research. This research is aimed to determine hesperidin (HES) solubility in water and DES solvents [choline chloride/citric acid (ChCl/CA), choline chloride/oxalic acid (ChCl/OA), choline chloride/malonic acid (ChCl/MA), and choline chloride/lactic acid (ChCl/LA)] at temperature range (298.15–313.15 K). Furthermore, the measured solubility data of HES in studied aqueous DESs solutions was fitted by models of Van’t Hoff–Jouyban–Acree and Modified Apelblat–Jouyban–Acree. Finally, the Hansen solubility parameters as thermodynamic aspect for analyzing the dissolution processes for the four investigated aqueous DESs solutions were estimated.
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spelling pubmed-103386322023-07-14 Solubility of hesperidin drug in aqueous biodegradable acidic choline chloride-based deep eutectic solvents Shekaari, Hemayat Zafarani-Moattar, Mohammed Taghi Mokhtarpour, Masumeh Faraji, Saeid Sci Rep Article Important efforts have been made over the past years to improve the drug acts, which leads to the discovery of novel drug preparations and delivery systems. The selection of suitable green solvents for novel drug discovery and drug delivery depends on a molecular-level understanding of the interaction between drug molecules and the solvents. Deep eutectic solvents (DESs) are already used in sustainable extraction methods of natural products for their very high solvent power, high chemical and thermal stability, non-toxicity, and non-flammable. The thermodynamic investigation provides deep and complete knowledge of interactions and the choice of appropriate and suitable production compounds in pharmaceutical fields. Particularly, the analysis of drugs+DESs in aqueous media is a central issue in many types of research. This research is aimed to determine hesperidin (HES) solubility in water and DES solvents [choline chloride/citric acid (ChCl/CA), choline chloride/oxalic acid (ChCl/OA), choline chloride/malonic acid (ChCl/MA), and choline chloride/lactic acid (ChCl/LA)] at temperature range (298.15–313.15 K). Furthermore, the measured solubility data of HES in studied aqueous DESs solutions was fitted by models of Van’t Hoff–Jouyban–Acree and Modified Apelblat–Jouyban–Acree. Finally, the Hansen solubility parameters as thermodynamic aspect for analyzing the dissolution processes for the four investigated aqueous DESs solutions were estimated. Nature Publishing Group UK 2023-07-12 /pmc/articles/PMC10338632/ /pubmed/37438381 http://dx.doi.org/10.1038/s41598-023-38120-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Shekaari, Hemayat
Zafarani-Moattar, Mohammed Taghi
Mokhtarpour, Masumeh
Faraji, Saeid
Solubility of hesperidin drug in aqueous biodegradable acidic choline chloride-based deep eutectic solvents
title Solubility of hesperidin drug in aqueous biodegradable acidic choline chloride-based deep eutectic solvents
title_full Solubility of hesperidin drug in aqueous biodegradable acidic choline chloride-based deep eutectic solvents
title_fullStr Solubility of hesperidin drug in aqueous biodegradable acidic choline chloride-based deep eutectic solvents
title_full_unstemmed Solubility of hesperidin drug in aqueous biodegradable acidic choline chloride-based deep eutectic solvents
title_short Solubility of hesperidin drug in aqueous biodegradable acidic choline chloride-based deep eutectic solvents
title_sort solubility of hesperidin drug in aqueous biodegradable acidic choline chloride-based deep eutectic solvents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338632/
https://www.ncbi.nlm.nih.gov/pubmed/37438381
http://dx.doi.org/10.1038/s41598-023-38120-x
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