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Parametric delineation uncertainties contouring (PDUC) modeling on CT scans of prostate cancer patients

PURPOSE: Variability in contouring contributes to large variations in radiation therapy planning and treatment outcomes. The development and testing of tools to automatically detect contouring errors require a source of contours that includes well‐understood and realistic errors. The purpose of this...

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Autores principales: Ly, Vi, Liu, Lizhong, Cardenas, Carlos, Maroongroge, Sean, De, Brian, Basha, Daniel El, Court, Laurence, Luo, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338799/
https://www.ncbi.nlm.nih.gov/pubmed/37078392
http://dx.doi.org/10.1002/acm2.13970
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author Ly, Vi
Liu, Lizhong
Cardenas, Carlos
Maroongroge, Sean
De, Brian
Basha, Daniel El
Court, Laurence
Luo, Xi
author_facet Ly, Vi
Liu, Lizhong
Cardenas, Carlos
Maroongroge, Sean
De, Brian
Basha, Daniel El
Court, Laurence
Luo, Xi
author_sort Ly, Vi
collection PubMed
description PURPOSE: Variability in contouring contributes to large variations in radiation therapy planning and treatment outcomes. The development and testing of tools to automatically detect contouring errors require a source of contours that includes well‐understood and realistic errors. The purpose of this work was to develop a simulation algorithm that intentionally injects errors of varying magnitudes into clinically accepted contours and produces realistic contours with different levels of variability. METHODS: We used a dataset of CT scans from 14 prostate cancer patients with clinician‐drawn contours of the regions of interest (ROI) of the prostate, bladder, and rectum. Using our newly developed Parametric Delineation Uncertainties Contouring (PDUC) model, we automatically generated alternative, realistic contours. The PDUC model consists of the contrast‐based DU generator and a 3D smoothing layer. The DU generator transforms contours (deformation, contraction, and/or expansion) as a function of image contrast. The generated contours undergo 3D smoothing to obtain a realistic look. After model building, the first batch of auto‐generated contours was reviewed. Editing feedback from the reviews was then used in a filtering model for the auto‐selection of clinically acceptable (minor‐editing) DU contours. RESULTS: Overall, C values of 5 and 50 consistently produced high proportions of minor‐editing contours across all ROI compared to the other C values (0.936 [Formula: see text] 0.111 and 0.552 [Formula: see text] 0.228, respectively). The model performed best on the bladder, which had the highest proportion of minor‐editing contours (0.606) of the three ROI. In addition, the classification AUC for the filtering model across all three ROI is 0.724 [Formula: see text] 0.109. DISCUSSION: The proposed methodology and subsequent results are promising and could have a great impact on treatment planning by generating mathematically simulated alternative structures that are clinically relevant and realistic enough (i.e., similar to clinician‐drawn contours) to be used in quality control of radiation therapy.
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spelling pubmed-103387992023-07-14 Parametric delineation uncertainties contouring (PDUC) modeling on CT scans of prostate cancer patients Ly, Vi Liu, Lizhong Cardenas, Carlos Maroongroge, Sean De, Brian Basha, Daniel El Court, Laurence Luo, Xi J Appl Clin Med Phys Radiation Oncology Physics PURPOSE: Variability in contouring contributes to large variations in radiation therapy planning and treatment outcomes. The development and testing of tools to automatically detect contouring errors require a source of contours that includes well‐understood and realistic errors. The purpose of this work was to develop a simulation algorithm that intentionally injects errors of varying magnitudes into clinically accepted contours and produces realistic contours with different levels of variability. METHODS: We used a dataset of CT scans from 14 prostate cancer patients with clinician‐drawn contours of the regions of interest (ROI) of the prostate, bladder, and rectum. Using our newly developed Parametric Delineation Uncertainties Contouring (PDUC) model, we automatically generated alternative, realistic contours. The PDUC model consists of the contrast‐based DU generator and a 3D smoothing layer. The DU generator transforms contours (deformation, contraction, and/or expansion) as a function of image contrast. The generated contours undergo 3D smoothing to obtain a realistic look. After model building, the first batch of auto‐generated contours was reviewed. Editing feedback from the reviews was then used in a filtering model for the auto‐selection of clinically acceptable (minor‐editing) DU contours. RESULTS: Overall, C values of 5 and 50 consistently produced high proportions of minor‐editing contours across all ROI compared to the other C values (0.936 [Formula: see text] 0.111 and 0.552 [Formula: see text] 0.228, respectively). The model performed best on the bladder, which had the highest proportion of minor‐editing contours (0.606) of the three ROI. In addition, the classification AUC for the filtering model across all three ROI is 0.724 [Formula: see text] 0.109. DISCUSSION: The proposed methodology and subsequent results are promising and could have a great impact on treatment planning by generating mathematically simulated alternative structures that are clinically relevant and realistic enough (i.e., similar to clinician‐drawn contours) to be used in quality control of radiation therapy. John Wiley and Sons Inc. 2023-04-20 /pmc/articles/PMC10338799/ /pubmed/37078392 http://dx.doi.org/10.1002/acm2.13970 Text en © 2023 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, LLC on behalf of The American Association of Physicists in Medicine. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Ly, Vi
Liu, Lizhong
Cardenas, Carlos
Maroongroge, Sean
De, Brian
Basha, Daniel El
Court, Laurence
Luo, Xi
Parametric delineation uncertainties contouring (PDUC) modeling on CT scans of prostate cancer patients
title Parametric delineation uncertainties contouring (PDUC) modeling on CT scans of prostate cancer patients
title_full Parametric delineation uncertainties contouring (PDUC) modeling on CT scans of prostate cancer patients
title_fullStr Parametric delineation uncertainties contouring (PDUC) modeling on CT scans of prostate cancer patients
title_full_unstemmed Parametric delineation uncertainties contouring (PDUC) modeling on CT scans of prostate cancer patients
title_short Parametric delineation uncertainties contouring (PDUC) modeling on CT scans of prostate cancer patients
title_sort parametric delineation uncertainties contouring (pduc) modeling on ct scans of prostate cancer patients
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338799/
https://www.ncbi.nlm.nih.gov/pubmed/37078392
http://dx.doi.org/10.1002/acm2.13970
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