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Body mass index and risk of all-cause mortality among elderly Chinese: An empirical cohort study based on CLHLS data

The aim of our study was to evaluate the relationship between body mass index (BMI) and all-cause mortality among elderly Chinese. The subjects of our study were a cohort of 13 319 elderly Chinese enrolled between 2008 and 2018. Participants were classified in three groups: underweight (<18.5 kg/...

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Autores principales: Wang, Yun, Liu, Xuekui, Xue, Tongneng, Chen, Yu, Yang, Qianqian, Tang, Zhengwen, Chen, Lianhua, Zhang, Liqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339046/
https://www.ncbi.nlm.nih.gov/pubmed/37455755
http://dx.doi.org/10.1016/j.pmedr.2023.102308
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author Wang, Yun
Liu, Xuekui
Xue, Tongneng
Chen, Yu
Yang, Qianqian
Tang, Zhengwen
Chen, Lianhua
Zhang, Liqin
author_facet Wang, Yun
Liu, Xuekui
Xue, Tongneng
Chen, Yu
Yang, Qianqian
Tang, Zhengwen
Chen, Lianhua
Zhang, Liqin
author_sort Wang, Yun
collection PubMed
description The aim of our study was to evaluate the relationship between body mass index (BMI) and all-cause mortality among elderly Chinese. The subjects of our study were a cohort of 13 319 elderly Chinese enrolled between 2008 and 2018. Participants were classified in three groups: underweight (<18.5 kg/m(2)), normal weight (18.5–24.9 kg/m(2)), overweight and obese (≥25 kg/m(2)) according to different BMI levels. Cox proportional-hazards regression model was used to analyze the association between BMI grouping and the risk of mortality among the three groups and each corresponding subgroup. The restricted cubic spline regression was performed to investigate the variation tendency of BMI and mortality in different groups and subgroups. We found that the hazard ratios (HRs) of mortality in the underweight and the normal-weight groups were 1.213 and 1.104, respectively, compared with those in the overweight and obesity groups. HR for mortality decreased as BMI increased, although this phenomenon was not observed as not a linear relationship in all participants. Nonetheless, this nonlinear relationship was significant in type 2 diabetes patients. Among subjects with non-type 2 diabetes, the shape of the negative curve, reflecting the HR for BMI and mortality, decreased when BMI increased. Our findings suggest that an obesity paradox exists in non-type 2 diabetes patients, in which BMI has a nonlinear negative relationship with mortality. Conversely, in type 2 diabetes patients there is a U-shaped association. Obesity may thus be protective for all-cause mortality among non-diabetic older populations.
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spelling pubmed-103390462023-07-14 Body mass index and risk of all-cause mortality among elderly Chinese: An empirical cohort study based on CLHLS data Wang, Yun Liu, Xuekui Xue, Tongneng Chen, Yu Yang, Qianqian Tang, Zhengwen Chen, Lianhua Zhang, Liqin Prev Med Rep Regular Article The aim of our study was to evaluate the relationship between body mass index (BMI) and all-cause mortality among elderly Chinese. The subjects of our study were a cohort of 13 319 elderly Chinese enrolled between 2008 and 2018. Participants were classified in three groups: underweight (<18.5 kg/m(2)), normal weight (18.5–24.9 kg/m(2)), overweight and obese (≥25 kg/m(2)) according to different BMI levels. Cox proportional-hazards regression model was used to analyze the association between BMI grouping and the risk of mortality among the three groups and each corresponding subgroup. The restricted cubic spline regression was performed to investigate the variation tendency of BMI and mortality in different groups and subgroups. We found that the hazard ratios (HRs) of mortality in the underweight and the normal-weight groups were 1.213 and 1.104, respectively, compared with those in the overweight and obesity groups. HR for mortality decreased as BMI increased, although this phenomenon was not observed as not a linear relationship in all participants. Nonetheless, this nonlinear relationship was significant in type 2 diabetes patients. Among subjects with non-type 2 diabetes, the shape of the negative curve, reflecting the HR for BMI and mortality, decreased when BMI increased. Our findings suggest that an obesity paradox exists in non-type 2 diabetes patients, in which BMI has a nonlinear negative relationship with mortality. Conversely, in type 2 diabetes patients there is a U-shaped association. Obesity may thus be protective for all-cause mortality among non-diabetic older populations. 2023-06-30 /pmc/articles/PMC10339046/ /pubmed/37455755 http://dx.doi.org/10.1016/j.pmedr.2023.102308 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Wang, Yun
Liu, Xuekui
Xue, Tongneng
Chen, Yu
Yang, Qianqian
Tang, Zhengwen
Chen, Lianhua
Zhang, Liqin
Body mass index and risk of all-cause mortality among elderly Chinese: An empirical cohort study based on CLHLS data
title Body mass index and risk of all-cause mortality among elderly Chinese: An empirical cohort study based on CLHLS data
title_full Body mass index and risk of all-cause mortality among elderly Chinese: An empirical cohort study based on CLHLS data
title_fullStr Body mass index and risk of all-cause mortality among elderly Chinese: An empirical cohort study based on CLHLS data
title_full_unstemmed Body mass index and risk of all-cause mortality among elderly Chinese: An empirical cohort study based on CLHLS data
title_short Body mass index and risk of all-cause mortality among elderly Chinese: An empirical cohort study based on CLHLS data
title_sort body mass index and risk of all-cause mortality among elderly chinese: an empirical cohort study based on clhls data
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339046/
https://www.ncbi.nlm.nih.gov/pubmed/37455755
http://dx.doi.org/10.1016/j.pmedr.2023.102308
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