Cargando…

Large-scale metabolomic profiling and incident non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent disease with no specific drug therapy. High-throughput metabolomics present an unprecedented opportunity to identify biomarkers and potentially causal risk factors for NAFLD. Here, we determined the impact of 21 circulating metabolites,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gagnon, Eloi, Manikpurage, Hasanga D., Mitchell, Patricia L., Girard, Arnaud, Gobeil, Émilie, Bourgault, Jérôme, Bégin, Frédéric, Marette, André, Thériault, Sébastien, Arsenault, Benoit J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339047/ https://www.ncbi.nlm.nih.gov/pubmed/37456853 http://dx.doi.org/10.1016/j.isci.2023.107127

Ejemplares similares

Blood Levels of the SMOC1 Hepatokine Are Not Causally Linked with Type 2 Diabetes: A Bidirectional Mendelian Randomization Study
por: Ghodsian, Nooshin, et al.
Publicado: (2021)

Mendelian Randomization Analysis Identifies Blood Tyrosine Levels as a Biomarker of Non-Alcoholic Fatty Liver Disease
por: Gobeil, Émilie, et al.
Publicado: (2022)

Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease
por: Ghodsian, Nooshin, et al.
Publicado: (2021)

Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases
por: Gagnon, Eloi, et al.
Publicado: (2022)

Sex‐Specific Impact of Body Weight on Atherosclerotic Cardiovascular Disease Incidence in Individuals With and Without Ideal Cardiovascular Health
por: Paulin, Audrey, et al.
Publicado: (2023)

Greater adherence to the 2019 Canada's Food Guide recommendations on healthy food choices reduces the risk of cardiovascular disease in adults: a prospective analysis of UK Biobank data
por: Brassard, Didier, et al.
Publicado: (2022)

Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: a Mendelian randomization study
por: Gagnon, Eloi, et al.
Publicado: (2023)

Genome-Wide Meta-Analysis and Mendelian Randomization Identify Early Biomarkers of Non-Alcoholic Fatty Liver Disease
por: Gobeil, Emilie, et al.
Publicado: (2021)

Electronic Health Record-Based Genome-Wide Meta-Analysis Identifies New Susceptibility Loci for Non-Alcoholic Fatty Liver Disease
por: Ghodsian, Nooshin, et al.
Publicado: (2021)

Impact of C-reactive protein levels on lipoprotein(a)-associated aortic stenosis incidence and progression
por: Girard, Arnaud, et al.
Publicado: (2023)

A trans‐omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases
por: Perrot, Nicolas, et al.
Publicado: (2021)

Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis
por: Bourgeois, Raphaëlle, et al.
Publicado: (2021)

Obesity, Body Fat Distribution, and Circulating Glutamate Concentrations, A BI-Directional Mendelian Randomization Study
por: Maltais-Payette, Ina, et al.
Publicado: (2021)

A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity
por: Rosa, Mickael, et al.
Publicado: (2019)

Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery disease
por: Chignon, Arnaud, et al.
Publicado: (2022)

Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis
por: Li, Zhonglin, et al.
Publicado: (2020)

Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases
por: Chignon, Arnaud, et al.
Publicado: (2020)

Prevalence of cutaneous and mucosal lesions in dairy cattle admitted to a Canadian Veterinary Teaching Hospital from 2018 to 2019
por: Guarnieri, Eloi, et al.
Publicado: (2023)

Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis
por: Perrot, Nicolas, et al.
Publicado: (2020)

Mendelian randomization of circulating proteome identifies actionable targets in heart failure
por: Moncla, Louis-Hippolyte Minvielle, et al.
Publicado: (2022)

Association of Metabolomic Change and Treatment Response in Patients with Non-Alcoholic Fatty Liver Disease
por: Lee, Kwang Seob, et al.
Publicado: (2022)

Fecal Metagenomics and Metabolomics Identifying Microbial Signatures in Non-Alcoholic Fatty Liver Disease
por: Pekkala, Satu
Publicado: (2023)

A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization
por: Bourgeois, Raphaëlle, et al.
Publicado: (2020)

Fish and Marine Omega-3 Polyunsatured Fatty Acid Consumption and Incidence of Type 2 Diabetes: A Systematic Review and Meta-Analysis
por: Zhang, Ming, et al.
Publicado: (2013)

Longitudinal Changes in Cholesterol Efflux Capacities in Patients With Coronary Artery Disease Undergoing Lifestyle Modification Therapy
por: Boyer, Marjorie, et al.
Publicado: (2018)

Metabolomic analysis of human cirrhosis, hepatocellular carcinoma, non-alcoholic fatty liver disease and non-alcoholic steatohepatitis diseases
por: Safaei, Akram, et al.
Publicado: (2016)

Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms
por: Mathieu, Samuel, et al.
Publicado: (2022)

Acute Effects of Single Doses of Bonito Fish Peptides and Vitamin D on Whole Blood Gene Expression Levels: A Randomized Controlled Trial
por: Guénard, Frédéric, et al.
Publicado: (2019)

Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?
por: Martin-Grau, Maria, et al.
Publicado: (2022)

Application of metabolomics in the diagnosis of non-alcoholic fatty liver disease and the treatment of traditional Chinese medicine
por: Shao, Mingmei, et al.
Publicado: (2022)

Manipulation of Alcohol and Short-Chain Fatty Acids in the Metabolome of Commensal and Virulent Klebsiella pneumoniae by Linolenic Acid
por: Huang, Ryan Yuki, et al.
Publicado: (2020)

Case-finding strategies in non-alcoholic fatty liver disease
por: Boursier, Jerome, et al.
Publicado: (2020)

International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E(2) Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions
por: Norel, Xavier, et al.
Publicado: (2020)

Effects of isomaltulose on insulin resistance and metabolites in patients with non-alcoholic fatty liver disease: A metabolomic analysis
por: Kawaguchi, Takumi, et al.
Publicado: (2018)

Systems Genetics of Hepatic Metabolome Reveals Octopamine as a Target for Non-Alcoholic Fatty Liver Disease Treatment
por: Brial, Francois, et al.
Publicado: (2019)

Two Metabolomics Phenotypes of Human Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease According to Fibrosis Severity
por: Buchard, Benjamin, et al.
Publicado: (2021)

Accurate non‐invasive diagnosis and staging of non‐alcoholic fatty liver disease using the urinary steroid metabolome
por: Moolla, Ahmad, et al.
Publicado: (2020)

Exploring the underlying mechanisms of Ashitaba in the management of non-alcoholic fatty liver disease by integrating the analysis of transcriptomics and metabolomics
por: Yang, Huan, et al.
Publicado: (2023)

Hypoxia in the St. Lawrence Estuary: How a Coding Error Led to the Belief that “Physics Controls Spatial Patterns”
por: Bourgault, Daniel, et al.
Publicado: (2015)

Alcohol-induced metabolomic differences in humans
por: Jaremek, M, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_52924qn0st3c9qdj3n9fpcfq6q