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An integrated measure of GABA to characterize post-stroke plasticity
Stroke is a major cause of death and chronic neurological disability. Despite the improvements in stroke care, the number of patients affected by stroke keeps increasing and many stroke survivors are left permanently disabled. Current therapies are limited in efficacy. Understanding the neurobiologi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339061/ https://www.ncbi.nlm.nih.gov/pubmed/37406594 http://dx.doi.org/10.1016/j.nicl.2023.103463 |
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author | Paparella, Ilenia Vanderwalle, Gilles Stagg, Charlotte J. Maquet, Pierre |
author_facet | Paparella, Ilenia Vanderwalle, Gilles Stagg, Charlotte J. Maquet, Pierre |
author_sort | Paparella, Ilenia |
collection | PubMed |
description | Stroke is a major cause of death and chronic neurological disability. Despite the improvements in stroke care, the number of patients affected by stroke keeps increasing and many stroke survivors are left permanently disabled. Current therapies are limited in efficacy. Understanding the neurobiological mechanisms underlying post-stroke recovery is therefore crucial to find new therapeutic options to address this medical burden. Long-lasting and widespread alterations of γ-aminobutyric acid (GABA) neurotransmission seem to play a key role in stroke recovery. In this review we first discuss a possible model of GABAergic modulation of post-stroke plasticity. We then overview the techniques currently available to non-invasively assess GABA in patients and the conclusions drawn from this limited body of work. Finally, we address the remaining open questions to clarify GABAergic changes underlying post-stroke recovery, we briefly review possible ways to modulate GABA post stroke and propose a novel approach to thoroughly quantify GABA in stroke patients, by integrating its concentration, the activity of its receptors and its link with microstructural changes. |
format | Online Article Text |
id | pubmed-10339061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103390612023-07-14 An integrated measure of GABA to characterize post-stroke plasticity Paparella, Ilenia Vanderwalle, Gilles Stagg, Charlotte J. Maquet, Pierre Neuroimage Clin Review Article Stroke is a major cause of death and chronic neurological disability. Despite the improvements in stroke care, the number of patients affected by stroke keeps increasing and many stroke survivors are left permanently disabled. Current therapies are limited in efficacy. Understanding the neurobiological mechanisms underlying post-stroke recovery is therefore crucial to find new therapeutic options to address this medical burden. Long-lasting and widespread alterations of γ-aminobutyric acid (GABA) neurotransmission seem to play a key role in stroke recovery. In this review we first discuss a possible model of GABAergic modulation of post-stroke plasticity. We then overview the techniques currently available to non-invasively assess GABA in patients and the conclusions drawn from this limited body of work. Finally, we address the remaining open questions to clarify GABAergic changes underlying post-stroke recovery, we briefly review possible ways to modulate GABA post stroke and propose a novel approach to thoroughly quantify GABA in stroke patients, by integrating its concentration, the activity of its receptors and its link with microstructural changes. Elsevier 2023-06-25 /pmc/articles/PMC10339061/ /pubmed/37406594 http://dx.doi.org/10.1016/j.nicl.2023.103463 Text en © 2023 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Paparella, Ilenia Vanderwalle, Gilles Stagg, Charlotte J. Maquet, Pierre An integrated measure of GABA to characterize post-stroke plasticity |
title | An integrated measure of GABA to characterize post-stroke plasticity |
title_full | An integrated measure of GABA to characterize post-stroke plasticity |
title_fullStr | An integrated measure of GABA to characterize post-stroke plasticity |
title_full_unstemmed | An integrated measure of GABA to characterize post-stroke plasticity |
title_short | An integrated measure of GABA to characterize post-stroke plasticity |
title_sort | integrated measure of gaba to characterize post-stroke plasticity |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339061/ https://www.ncbi.nlm.nih.gov/pubmed/37406594 http://dx.doi.org/10.1016/j.nicl.2023.103463 |
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