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Y225A induces long-range conformational changes in human prion protein that are protective in Drosophila

Prion protein (PrP) misfolding is the key trigger in the devastating prion diseases. Yet the sequence and structural determinants of PrP conformation and toxicity are not known in detail. Here, we describe the impact of replacing Y225 in human PrP with A225 from rabbit PrP, an animal highly resistan...

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Detalles Bibliográficos
Autores principales:	Myers, Ryan R., John, Aliciarose, Zhang, Weiguanliu, Zou, Wen-Quan, Cembran, Alessandro, Fernandez-Funez, Pedro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339063/ https://www.ncbi.nlm.nih.gov/pubmed/37269948 http://dx.doi.org/10.1016/j.jbc.2023.104881

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