Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity

Maintenance of metabolic homeostasis is secured by metabolite-sensing systems, which can be overwhelmed by constant macronutrient surplus in obesity. Not only the uptake processes but also the consumption of energy substrates determine the cellular metabolic burden. We herein describe a novel transc...

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Detalles Bibliográficos
Autores principales: Saito, Kenji, Sekiya, Motohiro, Kainoh, Kenta, Yoshino, Ryunosuke, Hayashi, Akio, Han, Song-Iee, Araki, Masaya, Ohno, Hiroshi, Takeuchi, Yoshinori, Tsuyuzaki, Tomomi, Yamazaki, Daichi, Wanpei, Chen, Hada, Lisa, Watanabe, Sho, Paramita Adi Putri, Putu Indah, Murayama, Yuki, Sugano, Yoko, Osaki, Yoshinori, Iwasaki, Hitoshi, Yahagi, Naoya, Suzuki, Hiroaki, Miyamoto, Takafumi, Matsuzaka, Takashi, Shimano, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article Collection: Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339064/
https://www.ncbi.nlm.nih.gov/pubmed/37286039
http://dx.doi.org/10.1016/j.jbc.2023.104890

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