Whole‐Body Metabolism and the Musculoskeletal Impacts of Targeting Activin A and Myostatin in Severe Osteogenesis Imperfecta

Mutations in the COL1A1 and COL1A2 genes, which encode type I collagen, are present in around 85%–90% of osteogenesis imperfecta (OI) patients. Because type I collagen is the principal protein composition of bones, any changes in its gene sequences or synthesis can severely affect bone structure. As...

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Detalles Bibliográficos
Autores principales: Omosule, Catherine L., Joseph, Dominique, Weiler, Brooke, Gremminger, Victoria L., Silvey, Spencer, Lafaver, Brittany N., Jeong, Youngjae, Kleiner, Sandra, Phillips, Charlotte L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339096/
https://www.ncbi.nlm.nih.gov/pubmed/37457877
http://dx.doi.org/10.1002/jbm4.10753

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