Impact of the Xinsorb Scaffold-Related Parameters on Platelet Reactivity in Patients with Single De Novo Coronary Artery Lesions Undergoing Clopidogrel Treatment

BACKGROUND: This study aimed to assess the relationship between stent parameters and platelet function, as well as the platelet reactivity profiles over time in patients treated with the Xinsorb scaffold. METHODS: Adenosine diphosphate-induced maximal amplitude was measured as clopidogrel on-treatme...

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Detalles Bibliográficos
Autores principales: Yu, Shushu, Wang, Mingliang, Yan, Meiyu, Wang, Bo, Xu, Yawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Turkish Society of Cardiology 2023
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339140/
https://www.ncbi.nlm.nih.gov/pubmed/37288850
http://dx.doi.org/10.14744/AnatolJCardiol.2023.3071
Descripción
Sumario:BACKGROUND: This study aimed to assess the relationship between stent parameters and platelet function, as well as the platelet reactivity profiles over time in patients treated with the Xinsorb scaffold. METHODS: Adenosine diphosphate-induced maximal amplitude was measured as clopidogrel on-treatment platelet reactivity using thrombelastography. High residual platelet reactivity was defined as MA(ADP) > 47 mm. Platelet function testing was induced at baseline, discharge, and 6- and 12-month visits. RESULTS: A total of 40 individuals undergoing Xinsorb scaffold implantation and platelet function testing were included. No adverse events were recorded during follow-up. No correlation was observed among thrombelastography indices, stent diameters, and stent coverage surface area. Significant correlation was found between MA(ADP) and lengths of stents (Spearman rank correlation = 0.324, P = .031). Multiple logistic regression analyses demonstrated that high levels of high-density lipoprotein cholesterol was an independent protective factor for high residual platelet reactivity (odds ratio = 0.049, 95% confidence interval = 0.011-0.296, P = .016). No significant risk factors were identified; MA(ADP) presented to be 20.6 [13.1-36.2] mm, 26.8 [18.2-35.0] mm, and 30.0 [19.6-33.4] mm 48 hours, 6 months, and 12 months after procedure, respectively; 12-month MA(ADP) was significantly higher than the 48-hour MA(ADP) (P = .026). There was no obvious trend for platelet response status over time. CONCLUSION: Among patients on a clopidogrel-based dual antiplatelet treatment regimen following Xinsorb scaffold implantation, stent parameters had no significant effects on platelet reactivity. The high residual platelet reactivity phenotype is relatively stable over time. High residual platelet reactivity is more likely to occur in patients with lower high-density lipoprotein cholesterol levels.

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