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Silencing of UTX Mitigates Aging-Associated Cardiac Fibrosis via Blocking Cardiac Fibroblasts-to-Myofibroblasts Trans-Differentiation

BACKGROUND: Cardiac fibrosis increases with age. Fibroblast activation plays an essential role in cardiac fibrosis. Histone modifications are involved in various chromatin-dependent processes. Attenuation of the histone H3 trimethylation on lysine 27 demethylase UTX by RNA interference or heterozygo...

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Detalles Bibliográficos
Autores principales:	Li, Chao, Lin, Tiantian, Li, Delin, Si, Daoyuan, Sun, Huan, Yang, Sibao, Zhang, Zhongfan, Zhang, Qian, Shi, Kaiyao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Turkish Society of Cardiology 2023
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339143/ https://www.ncbi.nlm.nih.gov/pubmed/37288854 http://dx.doi.org/10.14744/AnatolJCardiol.2023.2777

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